{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:09:30Z","timestamp":1791637770960,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Cellulitis is an acute bacterial infection of the skin. Initial treatment primarily consists of systemic antibiotic therapy. Compression therapy is subsequently introduced to reduce edema. However, the optimal timing for initiating compression therapy remains a subject of debate, as early application is thought to potentially exacerbate the infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This study was designed as a prospective, randomized controlled trial. Patients admitted for treatment of lower leg cellulitis were recruited and randomly assigned in a 1:1 ratio. In addition to standard therapy, the intervention group received compression therapy one day after initiation of antibiotic treatment, using medical adaptive compression wraps. C\u2010reactive protein (CRP) levels, reduction in erythema, and patient\u2010reported symptoms were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 34 patients were included in the analysis. Early application of medical adaptive compression wraps alleviated symptoms without causing complications. In patients with initial CRP levels above 50\u00a0mg\/dl at admission, CRP reduction occurred more rapidly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data suggest that the early application of medical adaptive compression wraps within 24 hours of initiating antibiotic treatment alleviates symptoms, supports recovery, and does not lead to worsening of inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15829","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T06:14:12Z","timestamp":1754979252000},"page":"1274-1280","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Treating cellulitis promptly with compression therapy reduces C\u2010reactive protein\u2010levels and symptoms \u2013 a randomized\u2010controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3701-8365","authenticated-orcid":false,"given":"S\u00f6ren","family":"Dr\u00e4ger","sequence":"first","affiliation":[{"name":"Department of Dermatology Allergology and Venereology University Medical Center Schleswig\u2010Holstein (UKSH), Campus L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Kiehne","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergology and Venereology University Medical Center Schleswig\u2010Holstein (UKSH), Campus L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Zinser","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergology and Venereology University Medical Center Schleswig\u2010Holstein (UKSH), Campus L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology University Hospital Duesseldorf  Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Kahle","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergology and Venereology University Medical Center Schleswig\u2010Holstein (UKSH), Campus L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.8825"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.11.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1549-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0353.2004.03028.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13790"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050664"},{"issue":"3","key":"e_1_2_7_10_1","first-page":"106","article-title":"[Compression therapy for inflammatory dermatoses of the legs]","volume":"149","author":"Dissemond J","year":"2024","journal-title":"Dtsch Med Wochenschr"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-020-04734-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-020-04682-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/lrb.2022.0029"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917197"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T14:03:52Z","timestamp":1764597832000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/ddg.15829"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15829","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2025-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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