{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:29:16Z","timestamp":1787938156947,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Pemphigoid diseases are primarily mediated by IgG or IgA autoantibodies against the cutaneous basement membrane zone (BMZ). Although recent observations suggest the existence of exclusively IgM\u2010mediated pemphigoid disease, a larger study is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This prospective multicenter study included ten patients with exclusive IgM deposition along the BMZ by direct immunofluorescence (IF). Circulating IgM was detected by indirect IF and immunoblotting with recombinant BP180.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort, four females and six males with a median age of 77\u00a0years, presented predominantly with prurigo\u2010like lesions without blisters and mucosal involvement. Sera from nine patients demonstrated linear IgM labeling the blister roof of human salt\u2010split skin by indirect IF. Four patients yielded IgM reactivity against BP180, but none against BP230. In none of the controls (n\u00a0=\u00a0100), anti\u2010BMZ IgM was seen by direct IF. 1\/30 and 3\/60 controls with or without pruritic non\u2010pemphigoid diseases revealed serum IgM reactivity against the BMZ, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IgM pemphigoid is characterized by exclusive tissue\u2010bound anti\u2010BMZ IgM, serum anti\u2010BMZ IgM reactivity with BP180 as main target antigen, a predominantly non\u2010bullous clinical phenotype, absence of mucosal involvement, and a rather mild disease course. Our findings indicate that IgM pemphigoid may represent a distinct entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15838","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T09:51:29Z","timestamp":1754473889000},"page":"1555-1564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and immunopathological spectrum of immunoglobulin M pemphigoid: a multicenter case series"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-8424","authenticated-orcid":false,"given":"Kaan","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology Heidelberg University Medical Faculty Mannheim  Mannheim 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