{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:19:30Z","timestamp":1791231570142,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T00:00:00Z","timestamp":1762041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Bullous pemphigoid (BP) is the most common autoimmune blistering disease in the Western world. While remission is achieved in the majority of BP patients by long\u2010term use of corticosteroids with or without immunomodulants\/immunosuppressants, national and international guidelines recommend adjuvant immunoadsorption (IA) in refractory patients. Here we investigated the safety and efficacy of IA in severe and\/or refractory BP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>\n                      10 BP patients (3 women, 7 men; mean age 69.7\u00a0years; range 52\u201381\u00a0years) were treated with IA on three consecutive days (LigaSorb\n                      <jats:sup>\u00ae<\/jats:sup>\n                      , Fresenius Medical Care) combined with oral prednisolone (0.5\u00a0mg\/kg BW per day, tapered), dapsone (1.5\u00a0mg\/kg BW per day), and lesional mometasone furoate ointment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Within 2 and 6\u00a0months after IA, 50% and 90% of patients showed complete remission on therapy, respectively. In all patients, serum anti\u2010BP180 IgG levels decreased significantly by an average of 89% and 73% immediately after the third IA and 4\u00a0weeks later, respectively. A total of 56 adverse events (AE) occurred during the 12\u2010month follow\u2010up. The majority of AE were of severity grade 2 (50%), 15 AE were classified as severe (grade 3\u20134).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IA can be considered as a relatively safe and effective adjuvant therapy for patients with severe or refractory BP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15909","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T07:03:04Z","timestamp":1762153384000},"page":"472-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adjuvant therapy of severe and\/or refractory bullous pemphigoid with immunoadsorption \u2013 A prospective monocenter pilot study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5318-5796","authenticated-orcid":false,"given":"Maike M.","family":"Holtsche","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology University of Oldenburg  Oldenburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Hammers","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1542-0732","authenticated-orcid":false,"given":"Artem","family":"Vorobyev","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck 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