{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:56:50Z","timestamp":1781859410896,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Prevalence rates of atopic diseases (atopic dermatitis [AD], allergic asthma [AA], and allergic rhinoconjunctivitis [ARC]) have increased in Germany. However, there is a lack of simultaneous consideration and of precise data on the spatiotemporal variation of these diseases. This study investigates the spatiotemporal variation of atopic diseases in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analyses based on outpatient care data (2011\u20102020) of all statutory health insured persons in Germany. Spatiotemporal analyses of prevalence rates were performed on county levels and statistical smoothing were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence rates increased for all three diseases. Moderate but significant (p\u00a0&lt;\u00a00.05) correlations were among others observed between ARC and AA (r\u00a0=\u00a00.47).<\/jats:p>\n                    <jats:p>Correlations with the east\u2010west gradient were significant for all diseases, meaning higher prevalence rates of AD in the east and higher prevalence rates of AA and ARC in the west. The correlation coefficients showed significant values between the north\u2010south gradient and AD, as well as between the north\u2010south gradient and AA, implying higher prevalences in northern Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prevalence rates for atopic diseases have increased over the past decade. Regional patterns are different for AD and the other atopic diseases. The reasons for the increase and the variations need to be analysed in detail with a view to improving prevention and health care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15926","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:19:51Z","timestamp":1768569591000},"page":"634-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional variations and temporal trends of atopic diseases in Germany"],"prefix":"10.1111","volume":"24","author":[{"given":"Marie","family":"Sander","sequence":"first","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE)  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4026-8728","authenticated-orcid":false,"given":"Matthias","family":"Augustin","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE)  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4118-1058","authenticated-orcid":false,"given":"Valerie","family":"Andrees","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE)  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hischke","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE)  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1541-2369","authenticated-orcid":false,"given":"Jobst","family":"Augustin","sequence":"additional","affiliation":[{"name":"Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE)  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21060"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265741"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06707.x"},{"key":"e_1_2_8_5_1","first-page":"1067","article-title":"Current Insights into Atopic March","volume":"8","author":"Tsuge M","year":"2021","journal-title":"Children (Basel)"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01907"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S315888"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-012-1652-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-017-0026-x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00103-011-1427-6","article-title":"Pr\u00e4valenz und sozio\u00f6konomische Bedeutung von Allergien in Deutschland [Prevalence and socio\u2010economic relevance of allergies in Germany]","volume":"55","author":"B\u00f6cking C","year":"2012","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-047806"},{"key":"e_1_2_8_12_1","first-page":"1","article-title":"On the measurement of concentration and variablility of characters","volume":"63","author":"Gini C","year":"2005","journal-title":"Metron"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00116466"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12942-017-0120-x"},{"key":"e_1_2_8_15_1","unstructured":"ESRI.Funktionsweise von r\u00e4umlicher Autokorrelation (Global Moran's I).2022. 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