{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:20:48Z","timestamp":1791566448424,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Anti\u2010melanoma differentiation\u2010associated gene 5 antibody\u2010positive (MDA5+) dermatomyositis (DM) is characterized by a high incidence of rapidly progressive interstitial lung disease (RP\u2010ILD). Unique transcriptomic signatures in patients with MDA5+ DM were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Peripheral blood mononuclear cells (PBMCs), skin, and muscle biopsies from 28 patients with MDA5+\/\u2013 DM were sequenced. Uniquely expressed transcripts identified using RNA sequencing analysis of PBMCs were further validated using quantitative reverse\u2010transcriptase polymerase chain reaction (qRT\u2010PCR). Receiver operating characteristic analysis was used to determine the diagnostic potential of the target genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In MDA5+ DM samples, components of antiviral defense, neutrophil migration, and immune\u2010associated pathways (in PBMCs), fatty acid metabolic processes (in skin), and antigen recognition (in muscle tissue) were upregulated. The expressions of defensin alpha 3 (\n                      <jats:italic>DEFA3<\/jats:italic>\n                      ), ribonuclease family member 2 (\n                      <jats:italic>RNASE2<\/jats:italic>\n                      ), and interferon alpha inducible protein 27 (\n                      <jats:italic>IFI27<\/jats:italic>\n                      ) were upregulated and exhibited good predictive values for RP\u2010ILD in MDA5+ DM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The activation of the IFN, virus\u2010associated, and aberrant immune response pathways, as well as fatty acid metabolic processes may be involved in MDA5+ DM pathogenesis.\n                      <jats:italic>IFI27<\/jats:italic>\n                      ,\n                      <jats:italic>DEFA3<\/jats:italic>\n                      , and\n                      <jats:italic>RNASE2<\/jats:italic>\n                      may contribute to RP\u2010ILD pathogenesis and serve as biomarkers of MDA5+ DM.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15937","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T14:12:54Z","timestamp":1766758374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptomic signatures in different tissues of anti\u2010MDA5 positive dermatomyositis: Uncovering genes with predictive potential for RP\u2010ILD"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-1724","authenticated-orcid":false,"given":"Ke","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Department of Rheumatology Shanghai Skin Disease Hospital School of Medicine Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-6243","authenticated-orcid":false,"given":"Qian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3061-9456","authenticated-orcid":false,"given":"Hailun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-371X","authenticated-orcid":false,"given":"Xintian","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Virology and Immunology Shanghai Institute of Immunity and Infection Center for Biosafety Mega\u2010Science Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-2716","authenticated-orcid":false,"given":"Cheng","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University  Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5548-5883","authenticated-orcid":false,"given":"Yanting","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0358-8933","authenticated-orcid":false,"given":"Yutong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2630-8460","authenticated-orcid":false,"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4953-3866","authenticated-orcid":false,"given":"Licheng","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3825-9662","authenticated-orcid":false,"given":"Yeping","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5490-8597","authenticated-orcid":false,"given":"Xuemei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-6458","authenticated-orcid":false,"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Center Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7900-0852","authenticated-orcid":false,"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-6427","authenticated-orcid":false,"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-8278","authenticated-orcid":false,"given":"Song","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third People's Hospital of Hangzhou  Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5908-6206","authenticated-orcid":false,"given":"Hua","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ruijin Hospital School of Medicine Shanghai Jiao Tong University  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