{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:13:44Z","timestamp":1783685624871,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background and objectives<\/jats:bold>\n                    : Palmoplantar pustulosis (PPP) is a chronic and refractory inflammatory skin disorder with unclear pathogenesis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods<\/jats:bold>\n                    : Ten PPP patients treated with upadacitinib were monitored to assess efficacy and safety. Immunofluorescence and immunohistochemistry were employed to evaluate Th1, Th2, and Th17 cell expressions, along with their associated cytokines in lesions on palms or soles from 16 PPP patients, 10 chronic eczema (CE) patients, 10 psoriasis vulgaris (PV) patients, and 7 healthy controls (HC).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : In PPP patients receiving upadacitinib, the shortest time to achieve PPPASI75 and PPPASI90 was 4\u00a0weeks and 8\u00a0weeks, respectively. The rates of patients achieving PPPASI90 at week 16, week 24, and\u00a0week 52 was 70 %, 100 %, and100 %, respectively. Th1 cells and IFN\u2010\u03b3 levels in PPP were comparable to CE and PV, and higher than HC. Th2 cells, IL\u20104, and IL\u201013 levels in PPP were similar to CE, and greater than HC and PV. Th17 cells, IL\u201017, and IL\u201036\u03b3 levels in PPP were comparable to PV, and more abundant than HC and CE.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Upadacitinib is a safe and effective option for PPP patients, which may be attributed to the complex Th1, Th2, and Th17 inflammatory responses associated with PPP.\n                  <\/jats:p>","DOI":"10.1111\/ddg.15944","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:38:38Z","timestamp":1768808318000},"page":"757-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of upadacitinib in palmoplantar pustulosis case series highlights the complex immune response patterns"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8618-2908","authenticated-orcid":false,"given":"Shao\u2010Zhen","family":"Mai","sequence":"first","affiliation":[{"name":"Department of Dermatology The Eighth Affiliated Hospital of Sun Yat\u2010Sen University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru\u2010Zeng","family":"Xue","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The University of Hong Kong\u2013Shenzhen Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Min","family":"Li","sequence":"additional","affiliation":[{"name":"Dermatology Hospital Southern Medical University  Guangzhou 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