{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:13:22Z","timestamp":1783685602939,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Preventive tuberculosis (TB) therapy before initiating MTX or IL\u201017\/IL\u201023\/IL\u201012\/23p40 inhibitors for latent tuberculosis infection (LTBI) is supported by indirect evidence of TB reactivations with TNF inhibitors. However, direct evidence for MTX or IL\u201017\/IL\u201023\/IL\u201012\/23p40 inhibitors is limited. To better evaluate the risk of TB reactivation, data on LTBI patients exposed to these medications without preventive TB therapy are necessary. This study was conducted as part of the update of the European and German psoriasis guidelines aimed to assess current LTBI screening and preventive treatment practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>An online survey was distributed via German, European and international dermatological societies, yielding 326 complete responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>LTBI screening was performed by 45% of respondents before MTX initiation and 95% before IL\u201017\/IL\u201023\/IL\u201012\/23p40 inhibitors. Preventive TB therapy was initiated \u201calways\u201d or \u201calmost always\u201d in 38% of MTX cases and \u201cnever\u201d or \u201calmost never\u201d in 31%. For IL\u201017\/IL\u201023\/IL\u201012\/23p40 inhibitors, preventive TB therapy was used in 66% of cases \u201calways\u201d or \u201calmost always,\u201d 16% case\u2010by\u2010case and 9% \u201cnever\u201d or \u201calmost never.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LTBI screening and preventive TB therapy for MTX lack standardization. While screening is common for IL\u201017\/IL\u201023\/IL\u201012\/23p40 inhibitors, a significant proportion of LTBI patients receive these treatments without preventive TB therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15948","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T10:04:47Z","timestamp":1764324287000},"page":"737-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Inconsistent standard of care for tuberculosis screening and preventive therapy before initiating systemic psoriasis treatment"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-8663","authenticated-orcid":false,"given":"Christoph","family":"Zeyen","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Division of Evidence\u2010Based Medicine (dEBM) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0207-7373","authenticated-orcid":false,"given":"Ruben","family":"Heuer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Division of Evidence\u2010Based Medicine (dEBM) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brit","family":"Haecker","sequence":"additional","affiliation":[{"name":"German Central Committee against Tuberculosis (DZK)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Schaberg","sequence":"additional","affiliation":[{"name":"German Central Committee against Tuberculosis (DZK)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nast","sequence":"additional","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Division of Evidence\u2010Based Medicine (dEBM) Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin corporate member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011110"},{"key":"e_1_2_8_3_1","article-title":"Adverse effects of biologics: a network meta\u2010analysis and Cochrane overview","volume":"2011","author":"Singh JA","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-012567"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22808"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16926"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14507_g"},{"key":"e_1_2_8_8_1","unstructured":"NICE.NICE guideline. 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