{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:13:44Z","timestamp":1783685624920,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background<\/jats:bold>\n                    : Erysipelas, caused by streptococci, should be treated with penicillin, while uncomplicated cellulitis (phlegmon), often caused by\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    , requires penicillinase\u2010resistant beta\u2010lactam antibiotics, which have a higher risk of adverse effects. Distinguishing between these infections is important. Constitutional symptoms like chills and fever may help in diagnosis. Therefore, we have compared retrospectively how frequently patients with erysipelas versus patients with cellulitis have experienced constitutional symptoms and whether they responded to penicillin.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and Methods<\/jats:bold>\n                    : We retrospectively evaluated patients with erysipelas or cellulitis admitted to the dermatology department of the university hospital Halle between January 2024 and January 2025. They had been managed according to an internal standard operation procedure for skin\u2010 and soft tissue infections.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : Of 76 erysipelas patients without other infections, 91.4% reported constitutional symptoms at or before erythema onset, among them 17 of 18 patients with recurrent erysipelas. In contrast, only 36.2% of 47 cellulitis patients experienced such symptoms, typically later and not before erythema. Of patients with erysipelas, 98.3% responded within 2\u00a0days to penicillin, including 21 patients who had experienced symptoms for already 4 to 10\u00a0days prior to therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Our findings suggest that early constitutional symptoms and characteristic erythema are reliable indicators for erysipelas. Erysipelas do not tend to heal promptly and spontaneously but respond reliably to penicillin.\n                  <\/jats:p>","DOI":"10.1111\/ddg.15957","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T12:19:12Z","timestamp":1768997952000},"page":"746-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Constitutional symptoms and response to Penicillin G in erysipelas and cellulitis \u2013 a monocentric, retrospective, explorative study"],"prefix":"10.1111","volume":"24","author":[{"given":"Helena","family":"Schieffers","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Halle Martin Luther University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-145X","authenticated-orcid":false,"given":"Cord","family":"Sunderk\u00f6tter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Halle Martin Luther University Halle\u2010Wittenberg  Halle (Saale) Germany"},{"name":"MSB Medical School Berlin University of Health and Medicine  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13790"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1071-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae267"},{"key":"e_1_2_7_6_1","unstructured":"Diagnosedaten der Patienten und Patientinnen in Krankenh\u00e4usern (einschl. Sterbe\u2010 und Stundenf\u00e4lle) \u2013 Fachserie 12 Reihe 6.2.1 \u2010 2016. Available from:https:\/\/www.destatis.de\/DE\/Themen\/Gesellschaft\u2010Umwelt\/Gesundheit\/Krankenhaeuser\/Publikationen\/Downloads\u2010Krankenhaeuser\/diagnosedaten\u2010krankenhaus\u20102120621167004.html) (Last accessed April 4 2025)."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu444"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01816-17"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2124"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkad263"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.10.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16111615"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01645222"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7369.864"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-019-01382-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-025-05537-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.74.Suppl_4.S21"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16494"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv181"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7198.1591"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548609021656"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2274-9"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.5414\/ALX02314E"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28335-3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00865-7"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14252"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.07.030"},{"issue":"6","key":"e_1_2_7_28_1","article-title":"Interventions for cellulitis and erysipelas","volume":"2010","author":"Kilburn SA","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30523-5"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/pgs.10.24"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62001-8"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ddg.15957","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.15957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T11:17:48Z","timestamp":1783682268000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.15957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/ddg.15957"],"URL":"https:\/\/doi.org\/10.1111\/ddg.15957","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}