{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:22:50Z","timestamp":1783448570614,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Background and Objectives<\/jats:bold>\n                    : Livedoid vasculopathy (LV) is a vascular occlusive disease, lacking a standardized treatment strategy. Sulodexide as a heparin\u2010like agent has demonstrated favorable efficacy and safety profiles in certain thrombotic disorders. This study is designed to evaluate the efficacy and safety of sulodexide in the treatment of LV.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and Methods<\/jats:bold>\n                    : In this single\u2010center prospective study, 35 patients diagnosed with LV were treated with sulodexide. Efficacy outcomes were assessed at standardized intervals: baseline and at weeks 1, 4, 8, 12 following treatment initiation.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    : A total of 35 patients receiving sulodexide therapy were enrolled in the study. Thirty\u2010one patients (88.6%) achieved complete clinical resolution with sulodexide monotherapy. Two patients (5.7%) withdrew due to suboptimal therapeutic response, while two others (5.7%) required adjunctive baricitinib. Eight (22.9%) mild adverse events related to sulodexide were reported. No moderate\u2010severe adverse events occurred.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    : Our study demonstrates that sulodexide monotherapy is a clinically effective and well\u2010tolerated therapeutic option for patients with LV. Adjunctive JAK inhibitor therapy, when clinically indicated, may yield superior therapeutic outcomes.\n                  <\/jats:p>","DOI":"10.1111\/ddg.15965","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T06:14:48Z","timestamp":1767420888000},"page":"928-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of livedoid vasculopathy with sulodexide: A prospective study of 35 cases"],"prefix":"10.1111","volume":"24","author":[{"given":"Fazhan","family":"Ban","sequence":"first","affiliation":[{"name":"Department of Dermatology Xijing Hospital The Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daopei","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xijing Hospital The Fourth Military Medical University  Xi'an 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