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Additionally, two\u2010sample Mendelian randomization and linkage disequilibrium score regression were performed to determine the genetic association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In both the blood biochemistry cohort and the nuclear magnetic resonance metabolome cohort, higher levels of total cholesterol, LDL, and cholesterol in large LDL were inversely associated with rosacea (HR\u00a0=\u00a00.90 [0.85\u20130.95], 0.91 [0.86\u20130.96], and 0.90 [0.85\u20130.95], respectively). Additionally, omega\u20103 was found to potentially reduce the risk of rosacea by increasing cholesterol levels in large LDL (OR\u00a0=\u00a00.88 [0.82\u20130.94]; mediated proportion\u00a0=\u00a061.56%). Mendelian randomization analyses further supported the protective effects of total cholesterol and cholesterol in large LDL against rosacea (OR\u00a0=\u00a00.70 [0.55\u20130.89] and 0.79 [0.62\u20130.99], respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that higher levels of total cholesterol and cholesterol in large LDL may decrease rosacea risk, while omega\u20103 could influence rosacea pathogenesis through modulation of cholesterol in large LDL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15978","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T08:56:06Z","timestamp":1771145766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of serum lipids and polyunsaturated fatty acids on rosacea: Insights from prospective cohort studies"],"prefix":"10.1111","author":[{"given":"Rui","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinyang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha 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University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Aging Biology Xiangya Hospital Central South University  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha 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