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However, growing evidence over the past decade has revealed that this disease is in fact far more heterogeneous than previously thought \u2013 both in its clinical manifestations and in the underlying molecular and immunological mechanisms. This short review explores the evolving conceptual framework used to analyze atopic dermatitis, encompassing clinical presentations (phenotypes), immune polarization profiles (immunotypes), and the background disease\u2010related and context\u2010related factors that shape them. The aim of this review is to highlight how such heterogeneity influences disease severity, progression, and therapeutic response, particularly in the context of increasingly personalized treatment strategies. By synthesizing accumulated scientific and clinical insights, this short review provides clinicians with a practical guide to navigating the complex spectrum of AD and its underlying therapeutic targets. Recognizing and interpreting this multidimensional variability is essential for understanding disease course and optimizing treatment selection.<\/jats:p>","DOI":"10.1111\/ddg.15991","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T14:14:14Z","timestamp":1765635254000},"page":"602-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering atopic dermatitis heterogeneity: a short review on the translational revolution from endotypes to immunotypes"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6799-3727","authenticated-orcid":false,"given":"Alvaro","family":"Prados\u2010Carmona","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitario San Cecilio  Granada Spain"},{"name":"Instituto Biosanitario de Granada Ibs  Granada Spain"},{"name":"Escuela Internacional de Posgrado Universidad de Granada, 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