{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T09:08:34Z","timestamp":1788858514271,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011034","name":"Instituto Espa\u00f1ol de Oceanograf\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011034","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigates the association of melanoma risk with total\u2010body nevus count and the presence of atypical nevi in younger (&lt;\u00a040 years) and older (&gt;\u00a060 years) individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A pooled analysis was conducted within the M\u2010SKIP project, based on multiple melanoma case\u2010control studies. Associations were assessed through study\u2010specific odds ratios (ORs), adjusted for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine case\u2010control studies were included, analyzing common nevi (2,674 melanoma cases\/2,343 controls) and atypical nevi (2,459 cases\/1,740 controls). High common nevus count was associated with increased melanoma risk in both younger (summary [s]OR\u00a0=\u00a02.56; 95% CI 1.64\u20104.01; I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a031%) and older individuals (sOR\u00a0=\u00a02.06; 95% CI 1.06\u20134.00; I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a067%), with no significant age\u2010group difference (p\u00a0=\u00a00.57). In contrast, younger individuals exhibited a markedly higher risk of melanoma associated with the presence of at least one atypical nevus (sOR\u00a0=\u00a04.84, 95% CI 2.18\u201310.76; I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a065%) compared to older individuals (sOR\u00a0=\u00a01.71 95%CI 1.07\u20132.74; I\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a039%), with a p value for the difference of 0.02.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest age\u2010specific differences in melanoma risk associated with nevus burden. Specifically, atypical nevi are a stronger risk factor in younger individuals. This could have significant implications for prevention strategies and clinical management, in particular for better identification of high\u2010risk groups for targeted secondary prevention efforts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.15992","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T07:33:36Z","timestamp":1773041616000},"page":"1221-1230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age\u2010specific melanoma risk associated with melanocytic nevi: a pooled analysis from the M\u2010SKIP project"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2332-9218","authenticated-orcid":false,"given":"Giulia","family":"Doi","sequence":"first","affiliation":[{"name":"Molecular and Pharmaco\u2010Epidemiology Unit Department of Experimental Oncology IEO European Institute of Oncology IRCCS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Molecular and Pharmaco\u2010Epidemiology Unit Department of Experimental Oncology IEO European Institute of Oncology IRCCS  Milan Italy"},{"name":"Department of Statistics and Quantitative Methods University of Milan\u2010Bicocca, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Dermatologic Clinic University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelleke","family":"Gruis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Newton\u2010Bishop","sequence":"additional","affiliation":[{"name":"Institute of Medical Research at St James's University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Polsky","sequence":"additional","affiliation":[{"name":"Ronald O. 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