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Die Krankheit wird von endogenen (Androgene, IGF\u20101, neuroendokrine Faktoren) und exogenen (<jats:italic>Propionibacterium acnes<\/jats:italic>, Di\u00e4t, mechanische Irritation, Inhaltsstoffe medizinischer oder kosmetischer Externa) Einfl\u00fcssen moduliert. Akne geht mit zum Teil hoher Morbidit\u00e4t einher und kann bereits bei leichter Auspr\u00e4gung eine erhebliche Verschlechterung der Lebensqualit\u00e4t bewirken. Zu Therapie stehen wirksame topische und systemische Behandlungsverfahren zur Verf\u00fcgung. 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