{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:54:23Z","timestamp":1781502863745,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T00:00:00Z","timestamp":1443225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:sec><jats:title>Hintergrund<\/jats:title><jats:p>Das sekund\u00e4re Plattenepithelkarzinom (<jats:italic>engl.<\/jats:italic> squamous cell carcinoma, SCC) ist eine seltene Komplikation bei chronischem Ulcus cruris venosum. \u00dcber seine Pathophysiologie und den klinischen Verlauf ist bislang wenig bekannt. Das aktuelle Marjolin\u2010Register geht aus einer Initiative der Arbeitsgruppe \u201eWundheilung\u201c (AGW) der Deutschen Dermatologischen Gesellschaft (DDG) hervor und erfasst F\u00e4lle von aus ven\u00f6sen Ulcera hervorgehenden Plattenepithelkarzinomen mit dem Ziel der Beurteilung diagnostischer Merkmale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patienten und Methoden<\/jats:title><jats:p>Alle Mitglieder der AGW beantworteten Frageb\u00f6gen \u00fcber Patientenbasisdaten, Ulkusmerkmale und die durchgef\u00fchrte Therapie.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ergebnisse<\/jats:title><jats:p>Zwischen 2010 und 2013 wurden 30 Patienten (20 Frauen, 10 M\u00e4nner) aus sechs terti\u00e4ren Wundbehandlungseinrichtungen registriert. Das Durchschnittsalter betrug 76,17 Jahre. Die durchschnittliche Dauer der Ulcera crurum venosa vor Diagnose des Plattenepithelkarzinoms betrug 15,93 Jahre. Als auff\u00e4llige Wundmerkmale wurden in erster Linie Schmerz (n = 3), Therapieresistenz (n = 27) und F\u00f6tor (n = 12) sowie ein klinisches Erscheinungsbild (n = 10) mit atypischer Morphologie, nodul\u00e4rem Wundbett und Hypergranulation festgestellt.<\/jats:p><\/jats:sec><jats:sec><jats:title>Schlussfolgerungen<\/jats:title><jats:p>Atypische Morphologie oder ver\u00e4ndertes Erscheinungsbild sowie Therapieresistenz trotz optimaler Versorgung (6\u201312 Wochen) sollten zum Anlass genommen werden, wenn n\u00f6tig mehrere und serielle spindelf\u00f6rmige Biopsien zu entnehmen. Die Hauptrisikofaktoren f\u00fcr eine maligne Transformation sind das Patientenalter und die Ulkusdauer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ddg.40_12649","type":"journal-article","created":{"date-parts":[[2015,9,26]],"date-time":"2015-09-26T10:14:56Z","timestamp":1443262496000},"page":"1006-1014","source":"Crossref","is-referenced-by-count":5,"title":["Plattenepithelkarzinome in chronischen ven\u00f6sen Ulcera crurum. 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