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The former German term \u201cgram\u2010negative foot infection\u201d misleadingly implied a soft\u2010tissue infection of the foot caused by gram\u2010negative bacteria. The updated term \u201cinfected interdigital intertrigo\u201d is an internationally used designation, as is the term \u201cgram\u2010negative toe web infection\u201d. This superficial infection may yet progress to soft tissue infection (phlegmon, cellulitis) of the foot but in immunocompetent patients is usually caused by\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    . Complicated courses, as well as the development of interdigital intertrigo itself, are facilitated by diabetes mellitus, polyneuropathy, and peripheral arterial disease. Diagnosis is made clinically, based on painful macerated erosions or ulcers with yellow\u2010green exudate, putrid odor and edema. Superficial swabs are not always diagnostically required or relevant. Management focuses on local therapy with anti\u2010inflammatory, antiseptic, antimycotic agents, dry wound care and reduction of edema. Systemic antibiotics are indicated only in cases of associated soft\u2010tissue infection, which in immunocompetent patients present as uncomplicated cellulitis and therefore require coverage limited to\n                    <jats:italic>S.\u00a0aureus<\/jats:italic>\n                    . Early vascular evaluation, imaging and surgical assessment in cases of deep infection or necrosis are essential.\n                  <\/jats:p>","DOI":"10.1111\/ddg.70040x","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T08:49:56Z","timestamp":1775033396000},"page":"832-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["S1 Guideline on Infected Interdigital Intertrigo (also called Gram\u2010Negative Toe Web Infection)"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-8663","authenticated-orcid":false,"given":"Christoph","family":"Zeyen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Division of Evidence\u2010based Medicine (dEBM) Charit\u00e9 \u2013Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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