{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:58:19Z","timestamp":1773007099158,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of this analysis was to assess the burden of hidradenitis suppurativa (HS) in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This was a retrospective German statutory health insurance claims data analysis covering the years 2020\u20132022 and 4.1 million individuals. An HS prevalence cohort and matched non\u2010HS cohort representing the general population were analyzed regarding burden of disease indicators. An HS incidence cohort was analyzed regarding flare occurrences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adult HS patients showed a significantly higher prevalence of comorbidities including a 3.58 (95% CI: 3.30; 3.85) higher prevalence for a mental\/behavioral disorder due to tobacco, 2.72 (95% CI: 2.61; 2.83) for obesity, 2.56 (95% CI: 2.40; 2.73) for diabetes, 2.00 (95% CI: 1.86; 2.14) for pain and 1.69 (95% CI: 1.62; 1.76) for depression compared to matched non\u2010HS individuals, respectively. HS patients aged \u2265 50 years had a numerically higher risk of death (risk ratio 1.57; 95% CI 0.96\u20132.17). Among deceased HS patients, the mean number of years of life lost ranged from 20.46 to 25.91 during the period 2020\u20132022. Finally, 24.4% experienced at least one HS flare requiring medical treatment within 24\u00a0months following their initial HS diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results of this analysis reveal that HS patients experience a substantial burden of disease compared to non\u2010HS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.70103","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:03:50Z","timestamp":1772964230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Burden of hidradenitis suppurativa in Germany: a retrospective claims data analysis and comparison with non\u2010HS patients"],"prefix":"10.1111","author":[{"given":"Falk G.","family":"Bechara","sequence":"first","affiliation":[{"name":"Department of Dermatology Venerology and Allergology ICH \u2013 International Centre for Hidradenitis suppurativa\/Acne inversa St. Josef\u2010Hospital Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Melnik","sequence":"additional","affiliation":[{"name":"Gesundheitsforen Leipzig GmbH  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-2412","authenticated-orcid":false,"given":"Tobias","family":"M\u00f6llers","sequence":"additional","affiliation":[{"name":"UCB Monheim am Rhein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Derk","family":"Pannen","sequence":"additional","affiliation":[{"name":"UCB Monheim am Rhein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romy","family":"Bley","sequence":"additional","affiliation":[{"name":"UCB Monheim am Rhein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Krampe","sequence":"additional","affiliation":[{"name":"Gesundheitsforen Leipzig GmbH  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-8433","authenticated-orcid":false,"given":"Luis","family":"M\u00f6ckel","sequence":"additional","affiliation":[{"name":"UCB Monheim am Rhein, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2225-7983"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15940"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16783"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2023.09.525"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00401-y"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508787"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.1301"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/actadv.v105.43124"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16101"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.014"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.030"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.06.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17578"},{"key":"e_1_2_9_15_1","volume-title":"Deutsche Gesellschaft f\u00fcr Medizinische Informatik, Biometrie und Epidemiologie, editors. 70. 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