{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:53:53Z","timestamp":1788893633157,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Atopic dermatitis (AD) may be complicated by disseminated molluscum contagiosum virus (MOCV) infection, known as eczema molluscatum (EM), particularly in children. Topical treatments are not always effective, and although modern systemic immunomodulatory therapies for AD, including use in early childhood, are available, their impact on co\u2010occurring MCV infection is not well documented. We present a 4\u2010year\u2010old child with severe EM that was refractory to conventional topical therapy. She was treated with dupilumab (300\u00a0mg subcutaneously every four weeks), which led to a rapid resolution of symptoms and clinical clearance of MOCV\u20101 infection without adverse events. To contextualize our findings, we performed a systematic literature review, including PubMed, ScienceDirect, Scopus, and Google Scholar, to identify published case descriptions of dupilumab use with co\u2010occurring MOCV infection (PROSPERO ID CRD420251106639). We identified a total of six publications reporting on nine adult patients (mean age: 40 years, range: 21\u201358 years, 8\/9 male). In five of these patients, EM temporarily flared up before resolution. The present report is the first of a child. Our findings, along with existing reports, suggest that dupilumab may be a safe and effective treatment option for AD patients with MOCV infection. Prospective evaluation using standardized outcome measures is warranted.<\/jats:p>","DOI":"10.1111\/ddg.70176","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:03:15Z","timestamp":1778248995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dupilumab for the treatment of eczema molluscatum: A pediatric case report and systematic literature review"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-9112","authenticated-orcid":false,"given":"Patrick E.","family":"Obermeier","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Vaccine Safety Initiative  Berlin Germany"},{"name":"Hautarztpraxis am R\u00fcdesheimer Platz  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uda","family":"Puzich","sequence":"additional","affiliation":[{"name":"Hautarztpraxis am R\u00fcdesheimer Platz  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Brinkmann","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens ZBS1 Highly Pathogenic Viruses &amp; German Consultant Laboratory for Poxviruses Robert Koch\u2010Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Schrick","sequence":"additional","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens ZBS1 Highly Pathogenic Viruses &amp; German Consultant Laboratory for Poxviruses Robert Koch\u2010Institute  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"M\u00fchlendyck","sequence":"additional","affiliation":[{"name":"Hautarztpraxis am R\u00fcdesheimer Platz  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02519-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.04.052"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15257"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.70045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01261-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.70060"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20674"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.14909"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp15X688093"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.12788\/cutis.0342"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18429"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.07.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-4053-1-2"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_9_16_1","unstructured":"National Heart Lung and Blood Institute.Study Quality Assessment Tools.2021. 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