{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T06:04:12Z","timestamp":1780293852760,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005713","name":"Technische Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Psoriasis Area and Severity Index (PASI) is the standard measure for psoriasis severity but reflects only a single time point and may underestimate long\u2010term disease burden. To assess whether the highest\u2010ever recorded PASI (PeakPASI) can serve as a marker of historical disease severity and correlate with treatment burden and comorbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional analysis of 308 psoriasis patients from a German university hospital was conducted. Data on PASI, PeakPASI, therapies, and comorbidities were obtained from self\u2010report and medical records. Group comparisons used non\u2010parametric tests; Poisson regression assessed PeakPASI as a predictor of systemic therapy use and comorbidity burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median PeakPASI (11.4 [IQR 5.9\u201317.0]) exceeded current PASI (2.0 [IQR 1.0\u20135.1]). PeakPASI \u2265\u00a010 was associated with more systemic therapies (p\u00a0&lt;\u00a00.001), phototherapy (p\u00a0&lt;\u00a00.001), smoking (p\u00a0=\u00a00.021), and diabetes (p\u00a0=\u00a00.020). PeakPASI correlated with number of systemic (\u03c1\u00a0=\u00a00.296), topical therapies (\u03c1\u00a0=\u00a00.367), and hospital visits (\u03c1\u00a0=\u00a00.186). It significantly predicted systemic therapy use (\u03b2\u00a0=\u00a00.355, p\u00a0&lt;\u00a00.001), but not comorbidity burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PeakPASI may complement current measures by reflecting historical severity and informing treatment. While not a cumulative burden marker, it may prevent underestimation of long\u2010term disease impact. Prospective validation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.70201","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:49:48Z","timestamp":1780292988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PeakPASI as a marker of maximum psoriasis severity: a single\u2010center, cross\u2010sectional retrospective and questionnaire\u2010based study"],"prefix":"10.1111","author":[{"given":"Simran","family":"Wilkhoo","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy TUM School of Medicine and Health Technical University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-1120","authenticated-orcid":false,"given":"Stefanie","family":"Ziehfreund","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy TUM School of Medicine and Health Technical University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8422-3278","authenticated-orcid":false,"given":"Enya","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy TUM School of Medicine and Health Technical University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Wecker","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy TUM School of Medicine and Health Technical University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Eyerich","sequence":"additional","affiliation":[{"name":"Center of Allergy and Environment (ZAUM) Technical University of Munich (TUM) and Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health  Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy TUM School of Medicine and Health Technical University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-6588","authenticated-orcid":false,"given":"Alexander","family":"Zink","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy TUM School of Medicine and Health Technical University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.13854","article-title":"A systematic review of worldwide epidemiology of psoriasis","volume":"31","author":"Michalek IM","year":"2017","journal-title":"J Eur Acad Dermatol 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