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We conducted a comprehensive review of clinical trials published between January 2000 and August 2025. 41\u00a0studies were included, exploring the use of beta\u2010blockers for any dermatological conditions, involving over 4,000\u00a0people worldwide. Our findings show strong evidence that beta\u2010blockers are the first\u2010line treatment for infantile hemangiomas. Additionally, they reduce mortality in patients with burns, accelerate wound healing in chronic venous and diabetic ulcers, and improve skin graft donor sites. Emerging data suggest benefits in rosacea, pyogenic granulomas, post\u2011procedural erythema, and as an adjunct to immune checkpoint inhibitors in melanoma, alongside a favorable safety profile in clinical trials. However, beta\u2011blockers can exacerbate inflammatory dermatoses, may interfere with the management of anaphylaxis, and exert complex effects on cutaneous immunity. Overall, beta\u2011blockers are evolving into versatile dermatologic tools whose expanding indications must be balanced against their immunologic and cardiovascular risks, and further high\u2011quality trials are needed to standardize their use in these emerging applications.<\/jats:p>","DOI":"10.1111\/ddg.70283","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:56:16Z","timestamp":1780037776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Scoping Review of Clinical Trials on the Expanding Role of Beta\u2011Blockers in Dermatology"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3745-5300","authenticated-orcid":false,"given":"Yasamin","family":"Dehghan","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Molecular Dermatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Gorjian","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Molecular Dermatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Rezaee","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Keshtkar","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Mahdi","family":"Parvizi","sequence":"additional","affiliation":[{"name":"Molecular Dermatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Hassannia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine School of medicine Kerman University of medical sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin Fazelzadeh","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Molecular Dermatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2970"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2023.2256218"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-025-07678-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2023.0209"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1489657"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00848-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1515901"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.879602"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.129"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1292722"},{"key":"e_1_2_7_12_1","first-page":"54","article-title":"Topical application of beta\u2010blockers accelerates epithelialization to mesh skin grafted full\u2010thickness burn in sheep","volume":"11","author":"Nakamoto K","year":"2024","journal-title":"Plastic and Aesthetic Research"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S391705"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15016"},{"key":"e_1_2_7_15_1","first-page":"955","article-title":"Immunologic adverse reactions of \u03b2\u2010blockers and the skin","volume":"18","author":"Tatu AL","year":"2019","journal-title":"Exp Ther Med"},{"key":"e_1_2_7_16_1","first-page":"32","article-title":"Drug\u2010provoked psoriasis: is it drug induced or drug aggravated? 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