{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:46:40Z","timestamp":1785836800895,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Digital pathology has become an increasingly established component of routine diagnostic practice in recent years. Whole\u2010slide imaging enables the complete digitization of histological slides and allows for primary diagnosis using digital images. This development offers new opportunities for diagnostics, consultations, archiving, education, and quality assurance. In dermatology and dermatopathology, digital pathology is particularly relevant for the evaluation of inflammatory skin diseases, melanocytic lesions, epithelial skin tumors, and immunohistochemical analyses. This article provides an overview of the technical principles of digital pathology, describes workflow integration and implementation in clinical routine, and outlines requirements for quality assurance and validation. Key applications in dermatology as well as advantages and limitations of digital diagnosis are discussed. A dedicated section addresses the role of artificial intelligence as an assistive tool in dermatopathological diagnostics. The aim of this CME article is to provide dermatologists and pathologists with a comprehensive basis for evaluating and applying digital pathology systems in clinical practice and to place current developments into a realistic clinical context.<\/jats:p>","DOI":"10.1111\/ddg.70482x","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:11:21Z","timestamp":1785834681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Digital Pathology in Dermatology \u2013 Current Status, Applications and Perspectives"],"prefix":"10.1111","volume":"24","author":[{"given":"Cornelia S. L.","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Medical Service Center for Histology Cytology and Molecular Pathology Trier, Germany"},{"name":"Saarland University Medical Faculty  Homburg\/Saar Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Hansen","sequence":"additional","affiliation":[{"name":"Medical Service Center for Histology Cytology and Molecular Pathology Trier, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"issue":"12","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.5858\/arpa.2013-0093-CP","article-title":"College of American Pathologists Pathology and Laboratory Quality Center. Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center","volume":"137","author":"Pantanowitz L","year":"2013","journal-title":"Arch Pathol Lab Med"},{"issue":"10","key":"e_1_2_13_3_1","article-title":"Transforming Diagnostics: A Comprehensive Review of Advances in Digital Pathology","volume":"16","author":"Fatima G","year":"2024","journal-title":"Cureus"},{"issue":"11","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/s41571-019-0252-y","article-title":"Artificial intelligence in digital pathology \u2010 new tools for diagnosis and precision oncology","volume":"16","author":"Bera K","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"issue":"10","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.5858\/arpa.2019-0569-OA","article-title":"Digital Whole Slide Imaging Compared With Light Microscopy for Primary Diagnosis in Surgical Pathology","volume":"144","author":"Borowsky AD","year":"2020","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00292-024-01401-x","article-title":"Stand der Digitalisierung in der Dermatopathologie [State of digitalization in dermatopathology]","volume":"46","author":"Braun SA","year":"2025","journal-title":"Pathologe"},{"issue":"4","key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.5858\/arpa.2020-0723-CP","article-title":"Validating Whole Slide Imaging Systems for Diagnostic Purposes in Pathology","volume":"146","author":"Evans AJ","year":"2022","journal-title":"Arch Pathol Lab Med"},{"issue":"12","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/jclinpath-2017-204644","article-title":"Future\u2010proofing pathology: the case for clinical adoption of digital pathology","volume":"70","author":"Williams BJ","year":"2017","journal-title":"J Clin Pathol"},{"issue":"4","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41416-020-01122-x","article-title":"Deep learning in cancer pathology: a new generation of clinical biomarkers","volume":"124","author":"Echle A","year":"2021","journal-title":"Br J Cancer"},{"issue":"2","key":"e_1_2_13_10_1","first-page":"101","article-title":"Whole Slide Images in Artificial Intelligence Applications in Digital Pathology: Challenges and Pitfalls","volume":"39","author":"Basak K","year":"2023","journal-title":"Turk Patoloji Derg"},{"issue":"12","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/cup.14866","article-title":"Decision Fatigue in Dermatopathology: Cognitive Load and Diagnostic Vulnerability","volume":"52","author":"M\u00fcller CSL","year":"2025","journal-title":"J Cutan Pathol"},{"issue":"11","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/cup.14861","article-title":"Cognitive Robustness in Dermatopathology\u2010Diagnostic Thinking Beyond Rules and Routines","volume":"52","author":"M\u00fcller CSL","year":"2025","journal-title":"J Cutan Pathol"},{"issue":"3","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/ddg.15985","article-title":"Defensive medicine in dermatological practice \u2010 Dermatopathology as a mirror of structural challenges","volume":"24","author":"M\u00fcller CSL","year":"2025","journal-title":"J Dtsch Dermatol Ges"},{"issue":"7","key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00105-025-05516-x","article-title":"Ausbildung im Zeitalter der Digitalisierung\u2013 Evaluation des digitalen M\u00fcnsteraner Dermatopathologiekurses [Training in the age of digitalization\u2010 evaluation of the digital M\u00fcnster dermatopathology course]","volume":"76","author":"Schmidle P","year":"2025","journal-title":"Dermatologie"},{"key":"e_1_2_13_15_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.ejca.2021.06.049","article-title":"Skin cancer classification via convolutional neural networks: systematic review of studies involving human experts","volume":"156","author":"Haggenm\u00fcller S","year":"2021","journal-title":"Eur J Cancer"}],"container-title":["JDDG: Journal der Deutschen Dermatologischen Gesellschaft"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.70482x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ddg.70482x","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ddg.70482x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:11:37Z","timestamp":1785834697000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ddg.70482x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ddg.70482x"],"URL":"https:\/\/doi.org\/10.1111\/ddg.70482x","archive":["Portico"],"relation":{},"ISSN":["1610-0379","1610-0387"],"issn-type":[{"value":"1610-0379","type":"print"},{"value":"1610-0387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}