{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:49:11Z","timestamp":1782989351681,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Near\u2010infrared non\u2010ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence\u2010dependent continuum of tissue modulation, based on evidence from 27\u00a0studies of lasers operating at 1540\u20131570\u00a0nanometers, comprising ten molecular biology studies and 17\u00a0histological analyses. Histological data demonstrated a fluence\u2010dependent tissue response: lower fluences preserved the stratum corneum, whereas higher fluences produced marked epidermal damage with subepidermal clefting, indicating a semi\u2010ablative pattern. Both histological and molecular findings supported parallel spatiotemporal remodeling cascade, consisting of an initial inflammatory phase dominated by neutrophil infiltration and upregulation of heat shock proteins, interleukins, and matrix metalloproteinases; followed by a proliferative phase within 24 hours, characterized by keratinocyte bridging, re\u2010epithelialization, and increased mitochondrial activity; and culminate in a prolonged remodeling phase (weeks 2\u201312), marked by collagen and elastin fibers synthesis and reorganization. By integrating evidence from molecular and histological studies, this review repositions NAFL within a fluence\u2010dependent continuum of tissue modulation, ranging from non\u2010ablative photothermal interactions to progressively barrier\u2010disruptive treatment modalities. This framework holds perspectives for broadening the clinical scope, particularly for applications in laser\u2010assisted drug delivery and skin cancer prevention.<\/jats:p>","DOI":"10.1111\/ddg.70487","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:56:13Z","timestamp":1782986173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repositioning Non\u2010Ablative Fractional Lasers \u2010 Molecular and Histological Insights from a scoping review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3975-0255","authenticated-orcid":false,"given":"Guy","family":"Erlich","sequence":"first","affiliation":[{"name":"Bispebjerg Hospital, Department of Dermatology  Copenhagen Denmark"},{"name":"Hillel\u2010Yaffe Hospital, Plastic Surgery Department  Hadera Israel"},{"name":"Technion Israel Institute of Technology, The Ruth and Bruce Rappaport Faculty of Medicine Haifa Israel"},{"name":"Meuhedet Health Maintenance Organization (HMO)  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Paasch","sequence":"additional","affiliation":[{"name":"Praxis Prof. Paasch and University of Leipzig, Germany, Department of Dermatology, Venerology and Allergy  Allergy Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-6638","authenticated-orcid":false,"given":"Kevin","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Bispebjerg Hospital, Department of Dermatology  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Haedersdal","sequence":"additional","affiliation":[{"name":"Bispebjerg Hospital, Department of Dermatology  Copenhagen Denmark"},{"name":"University of Copenhagen, Department of Clinical Medicine  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uffe H\u00f8gh","family":"Olesen","sequence":"additional","affiliation":[{"name":"Bispebjerg Hospital, Department of Dermatology  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"issue":"9","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1111\/ddg.14879","article-title":"S2k guideline: Laser therapy of the skin","volume":"20","author":"Paasch U","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"issue":"6","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/bjd.17076","article-title":"Laser treatments in early wound healing improve scar appearance: a randomized split\u2010wound trial with nonablative fractional laser exposures vs. untreated controls","volume":"179","author":"Karmisholt KE","year":"2018","journal-title":"Br J Dermatol"},{"key":"e_1_2_7_4_1","first-page":"1","article-title":"Principles and clinical 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