{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:52:45Z","timestamp":1792129965685,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Flat pigmented skin lesions in chronically sun\u2010exposed face and scalp areas present diagnostic challenges. Particularly, solar lentigo, pigmented actinic keratosis and lentigo maligna show overlapping features. Erroneous laser treatment of lentigo maligna for cosmetic reasons will inevitably delay diagnosis and compromise patient safety. This study assessed the performance of a market\u2010approved convolutional neural network (CNN) versus dermatologists in differentiating melanocytic from non\u2010melanocytic face and scalp lesions (FSL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Cross\u2010sectional two\u2010level reader study using 100 histologically validated FSL (level\u00a0I: dermoscopy only; level\u00a0II: expanded case information). The primary outcome was the diagnostic accuracy of the CNN in comparison to 64 dermatologists reviewing expanded case information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The CNN differentiated melanocytic and non\u2010melanocytic FSL with an accuracy (95% CI) of 79.0% (69.7%\u201386.5%) and a ROC\u2010AUC of 0.847 (0.772\u20130.923). Dermatologists reached a mean accuracy of 66.7% (64.7%\u201368.7%) at level\u00a0I, which increased to 73.6% (72.1%\u201375.1%; p\u00a0&lt;\u00a00.001) with expanded case information (level\u00a0II). Compared with dermatologists at level\u00a0II, the CNN demonstrated a significantly higher accuracy (79.0% vs. 73.6%; p\u00a0&lt;\u00a00.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that a CNN trained to differentiate melanocytic from non\u2010melanocytic FSL may improve clinicians\u2019 diagnostic accuracy when used as an AI\u2010based decision support tool for determining whether cosmetic laser procedures could safely be performed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.70530","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:33:22Z","timestamp":1792128802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When to refuse cosmetic treatment \u2013 AI\u2010decision support for differentiating melanocytic and non\u2010melanocytic facial lesions"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-9647","authenticated-orcid":false,"given":"Anastasia Sophie","family":"Vollmer","sequence":"first","affiliation":[{"name":"Department of Dermatology University medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Katharina","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Toberer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-2658","authenticated-orcid":false,"given":"Katharina Susanne","family":"Kommoss","sequence":"additional","affiliation":[{"name":"Department of Dermatology University medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Blum","sequence":"additional","affiliation":[{"name":"Public Private and Teaching Practice for Dermatology  Konstanz German"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hofmann\u2010Wellenhof","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Stolz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Allergology and Environmental Medicine II Hospital Thalkirchner Street  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Enk","sequence":"additional","affiliation":[{"name":"Department of Dermatology University medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7255-3104","authenticated-orcid":false,"given":"Holger Andreas","family":"Haenssle","sequence":"additional","affiliation":[{"name":"Department of Dermatology University medical Center Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clindermatol.2013.05.021","article-title":"Basic histological structure and functions of facial skin","volume":"32","author":"Arda O","year":"2014","journal-title":"Clin 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