{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:09:25Z","timestamp":1790060965141,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>As allergies against beta\u2010lactam antibiotics (BLA) are among the most common drug allergies, diagnostic testing is essential when an allergic reaction is suspected. To investigate the outcomes of allergy testing in patients with delayed\u2010type allergy to BLA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>The prevalence of delayed\u2010type allergy to aminopenicillins or other BLA as well as their cross\u2010reactivity, were analyzed by using skin testing (patch, prick, intradermal tests) and drug challenge testing (DCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Aminopenicillins were the most frequently suspected culprit drugs in the evaluated cohort (n\u00a0=\u00a0487), and delayed\u2010type allergy was confirmed in 29.9% of patients. DCT was positive despite negative skin test results in 6.0% (29\/487). Cross reactivity with closely related BLA groups were found in 10% (8\/80) of patients. Given that 88.9% (297\/334) of patients with previous negative skin test results tolerated the subsequent drug challenge without allergic reaction, the negative predictive value of skin testing appears reliable within a standardized clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thorough allergy diagnostic testing prevents re\u2010exposure to culprit drugs and enables the delabeling of patients with suspected drug allergy, thereby avoiding unnecessary treatment restrictions. Allergy testing is therefore an important and effective component of the diagnostic workup following a history of maculopapular exanthema.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.70534","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:45:02Z","timestamp":1790059502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of suspected delayed\u2010type allergy to beta\u2010lactam antibiotics: a 6\u2010year retrospective single center experience"],"prefix":"10.1111","author":[{"given":"Katharina","family":"Pietschke","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Uniklinik RWTH Aachen  Aachen Germany"},{"name":"Department of Dermatology University Hospital Tuebingen Eberhard Karls University Tuebingen  Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4220-8980","authenticated-orcid":false,"given":"Morna F.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Uniklinik RWTH Aachen  Aachen Germany"},{"name":"Aachen Comprehensive Allergy Center (ACAC) Uniklinik RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Wurpts","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Uniklinik RWTH Aachen  Aachen Germany"},{"name":"Aachen Comprehensive Allergy Center (ACAC) Uniklinik RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Tuebingen Eberhard Karls University Tuebingen  Tuebingen Germany"},{"name":"Department of Dermatology and Allergology University Hospital  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-3156","authenticated-orcid":false,"given":"Amir S.","family":"Yazdi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Uniklinik RWTH Aachen  Aachen Germany"},{"name":"Department of Dermatology University Hospital Tuebingen Eberhard Karls University Tuebingen  Tuebingen Germany"},{"name":"Aachen Comprehensive Allergy Center (ACAC) Uniklinik RWTH Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"issue":"10167","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(18)32218-9","article-title":"Antibiotic allergy","volume":"393","author":"Blumenthal KG","year":"2019","journal-title":"Lancet"},{"issue":"3","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1016\/j.jaci.2010.11.047","article-title":"Diagnosis and management of drug hypersensitivity reactions","volume":"127","author":"Romano A","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2386654"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13223-020-00494-2","article-title":"Practical guide for evaluation and management of beta\u2010lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology","volume":"16","author":"Jeimy S","year":"2020","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/JAA.S242061","article-title":"\u03b2\u2010Lactam Allergy and Cross\u2010Reactivity: A Clinician's Guide to Selecting an Alternative Antibiotic","volume":"14","author":"Caruso C","year":"2021","journal-title":"J Asthma Allergy"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-med-050913-022745","article-title":"T cell\u2010mediated hypersensitivity reactions to drugs","volume":"66","author":"Pavlos R","year":"2015","journal-title":"Annu Rev Med"},{"issue":"10","key":"e_1_2_7_8_1","first-page":"460","article-title":"Penicillin Allergy Delabeling Can Decrease Antibiotic Resistance, Reduce Costs, and Optimize Patient Outcomes","volume":"37","author":"Lee RU","year":"2020","journal-title":"Fed Pract"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5414\/ALX02310E","article-title":"Patients with questionable penicillin (beta\u2010lactam) allergy: Causes and solutions","volume":"6","author":"Brockow K","year":"2022","journal-title":"Allergol Select"},{"key":"e_1_2_7_10_1","first-page":"11","article-title":"Guideline on diagnostic procedures for suspected hypersensitivity to beta\u2010lactam antibiotics: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI) in collaboration with the German Society of Allergology (AeDA), German Society for Pediatric Allergology and Environmental Medicine (GPA), the German Contact Dermatitis Research Group (DKG), the Austrian Society for Allergology and Immunology (\u00d6GAI), and the Paul\u2010Ehrlich Society for Chemotherapy (PEG)","volume":"4","author":"Wurpts G","year":"2020","journal-title":"Allergol Select"},{"issue":"4","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.18176\/jiaci.0864","article-title":"Stability Over Time of In\u2010Hospital\u2010Compounded Amoxicillin Capsules and Ceftriaxone Patch Tests for Drug Allergy Testing","volume":"33","author":"Gond\u00e9 H","year":"2023","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5414\/ALX02314E","article-title":"Suspected allergy to Beta\u2010Lactam antibiotics: An infectiological perspective","volume":"6","author":"Sunderk\u00f6tter C","year":"2022","journal-title":"Allergol Select"},{"issue":"8","key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.3390\/antibiotics11081055","article-title":"Antibiotic Allergy De\u2010Labeling: A Pathway against Antibiotic Resistance","volume":"11","author":"Do\u00f1a I","year":"2022","journal-title":"Antibiotics"},{"issue":"1","key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.7326\/0003-4819-141-1-200407060-00010","article-title":"Cross\u2010Reactivity and Tolerability of Cephalosporins in Patients with Immediate Hypersensitivity to Penicillins","volume":"141","author":"Romano A","year":"2004","journal-title":"Ann Intern 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