{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:13:46Z","timestamp":1788509626167,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>Pegylated interferon\u2010\u03b12a became the off\u2010label alternative for treating mycosis fungoides\/S\u00e9zary syndrome (MF\/SS) after non\u2010pegylated interferons were withdrawn. This study aimed to evaluate the safety and efficacy of ropeginterferon\u2010\u03b12b in MF\/SS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>We performed a retrospective multicenter analysis at 5 Austrian centers and 1 Dutch center, including 41 patients with MF or SS who were treated with ropeginterferon\u2010\u03b12b between October 2024 and September 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 38 MF (early\u2010stage n\u00a0=\u00a016, advanced\u2010stage n\u00a0=\u00a022) and 3 SS patients. In 70.7 % of cases (29\/41), ropeginterferon\u2010\u03b12b was administered as part of a combination treatment with a mean dose of 100\u00a0\u00b5g every 2\u00a0weeks. We observed an overall response rate of 48.8 % over a median treatment duration of 6\u00a0months (range 1\u201311\u00a0months). Treatment was discontinued in 16 patients (39.0 %) after a median of 4\u00a0months because of progressive disease (n = 9), adverse events (n = 4), or other reasons (n = 3). Most frequent AEs were fatigue\/flu\u2010like symptoms (32.5 %), anemia (15 %), neutropenia (15 %), lymphopenia (10 %), and elevated liver enzymes (10 %), classified as grade 1 or 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Conclusions: This study provides initial evidence that ropeginterferon\u2010\u03b12b may be effective and well tolerated in patients with CTCL. Although interpretation is limited by the small retrospective cohort and short follow\u2010up, the observed outcomes appear comparable to those previously reported for other interferon\u2010\u03b1 formulations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.70546","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:49:30Z","timestamp":1788342570000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ropeginterferon\u2010\u03b12b in mycosis fungoides and S\u00e9zary syndrome: Safety and efficacy in 41 patients"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-0312","authenticated-orcid":false,"given":"Stefanie","family":"Porkert","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette M.","family":"Kersten","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanne","family":"Ottevanger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Schratter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Fink\u2010Puches","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"University Hospital for Dermatology Venereology and Allergology Medical University Innsbruck  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzaneh","family":"Sadeghyar","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital of St. Poelten Karl Landsteiner University of Health Sciences  St. Poelten Austria"},{"name":"Karl Landsteiner Institute of Dermatological Research  St. Poelten Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Latzka","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital of St. Poelten Karl Landsteiner University of Health Sciences  St. Poelten Austria"},{"name":"Karl Landsteiner Institute of Dermatological Research  St. Poelten 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