{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:25:35Z","timestamp":1793795135393,"version":"4.6.1"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Deutsche Derma Gesell"],"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Psoriasis is a systemic inflammatory disease affecting skin and mental health. Biologic agents targeting IL\u201017A and IL\u201023p19 effectively treat skin symptoms, but their psychiatric and systemic anti\u2010inflammatory effects remain unclear, especially in real\u2010life settings. This study evaluated whether IL\u201017A and IL\u201023p19 inhibitors improve psychiatric symptoms, and whether these improvements are associated with reductions in inflammatory markers, independently of skin response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>In this multicenter prospective study, 235\u00a0psoriasis patients starting IL\u201017A and IL\u201023p19 inhibitors were assessed at baseline and six months. Assessments included CRP, NLR, HADS\u2010A, HADS\u2010D, and DLQI scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Treatment significantly improved skin, quality of life, and psychiatric scores (p\u00a0&lt;\u00a00.001). CRP declined significantly and was independently correlated with reductions in HADS\u2010A and HADS\u2010D scores, even in patients without PASI90 response. IL\u201023p19 inhibitors produced greater reductions in CRP and NLR compared to IL\u201017A inhibitors, suggesting broader anti\u2010inflammatory effects through upstream cytokine blockade.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL\u201017A and IL\u201023p19 inhibitors improve both dermatological and psychiatric outcomes in psoriasis, potentially by reducing systemic inflammation. CRP may serve as a biomarker of psychiatric improvement, independent of skin response. Future studies with longer follow\u2010up and non\u2010biologic control groups are warranted. Integrating dermatological and psychiatric care may enhance outcomes in psoriasis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ddg.70579","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:46:39Z","timestamp":1791791199000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of IL\u201017A and IL\u201023p19 Inhibitors on Psychiatric Outcomes and Inflammation in Psoriasis"],"prefix":"10.1111","author":[{"given":"Ilknur K\u0131vanc","family":"Altunay","sequence":"first","affiliation":[{"name":"University of Health Sciences \u015ei\u015fli Hamidiye Etfal Training and Research Hospital Dermatology Department  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3780-5710","authenticated-orcid":false,"given":"Aysenur","family":"Demir","sequence":"additional","affiliation":[{"name":"University of Health Sciences \u015ei\u015fli Hamidiye Etfal Training and Research Hospital Dermatology Department  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-6790","authenticated-orcid":false,"given":"Ahmet","family":"Kayaalti","sequence":"additional","affiliation":[{"name":"University of Health Sciences \u015ei\u015fli Hamidiye Etfal Training and Research Hospital Dermatology Department  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sena Inal","family":"Aptoula","sequence":"additional","affiliation":[{"name":"Kanuni Sultan S\u00fcleyman Training and Research Hospital  Istanbul Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harbiye Dilek","family":"Canat","sequence":"additional","affiliation":[{"name":"University of Health Sciences Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital Dermatology Department  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan","family":"Engin","sequence":"additional","affiliation":[{"name":"Istanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa Faculty of Medicine Dermatology and Venereology Department  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf Can","family":"Erkoc","sequence":"additional","affiliation":[{"name":"Istanbul University\u2010Cerrahpa\u015fa Cerrahpa\u015fa Faculty of Medicine Dermatology and Venereology Department  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilteris Oguz","family":"Topal","sequence":"additional","affiliation":[{"name":"Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital Dermatology Department  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aslihan","family":"Kul","sequence":"additional","affiliation":[{"name":"Prof. Dr. Cemil Ta\u015fc\u0131o\u011flu City Hospital Dermatology Department  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.031237"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.07.008"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010179"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02376"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.788940"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073636"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-02823-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175452"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2019.31.6.601"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-01060-5"},{"key":"e_1_2_6_14_1","first-page":"25","article-title":"Assessing and Improving Psychological Well\u2010Being in Psoriasis: Considerations for the Clinician","volume":"12","author":"Blackstone B","year":"2022","journal-title":"Psoriasis (Auckl)"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.05.006"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19192"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-017-0279-8"},{"key":"e_1_2_6_18_1","unstructured":"Psoriasis and Cutaneous Inflammation Association.T\u00fcrkiye Psoriasis Treatment Guideline 2021. 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