{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:30:51Z","timestamp":1762176651013,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,3,31]],"date-time":"2013-03-31T00:00:00Z","timestamp":1364688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC96-2314-B-002-092-MY3"],"award-info":[{"award-number":["NSC96-2314-B-002-092-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with head and neck squamous cell carcinoma are at high risk for synchronous and\/or metachronous esophageal cancer. The present study aimed to evaluate the feasibility and safety of unsedated transnasal endoscopy (<jats:styled-content style=\"fixed-case\">TNE<\/jats:styled-content>) for screening these high\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Consecutive high\u2010risk patients including patients with suspicious or diagnosed head and neck cancer or patients with alarming symptoms received screening <jats:styled-content style=\"fixed-case\">TNE<\/jats:styled-content>. All endoscopic procedures, including sequential conventional white\u2010light, narrow\u2010band imaging, and <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ugol chromoendoscopy, were done without sedation. All suspicious lesions in the esophagus were biopsied for histological evaluation. The completion rate, procedure time, and significant adverse events of all endoscopic procedures were recorded and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2007 to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2011, a total of 500 <jats:styled-content style=\"fixed-case\">TNE<\/jats:styled-content> were carried out in 441 high\u2010risk patients. Among them, 294 patients (66.7%) had diagnosed head and neck squamous cellcarcinoma, and most were hypopharyngeal cancer (<jats:italic>n<\/jats:italic>\u2009=\u2009186). Esophageal squamous cell carcinomas and high\u2010grade intraepithelial neoplasms were detected in 10.1% and 7.3%, respectively, of the cases. Completion rate of <jats:styled-content style=\"fixed-case\">TNE<\/jats:styled-content> in head and neck cancer was 96.7%; tumor obstruction and stenosis of anastomosis site were the main reasons for incomplete procedures. Mean duration of the endoscopic procedure was 14.6\u2009min. One patient had post\u2010endoscopic epistaxis while another patient had post\u2010biopsy hemoptysis, both of whom were treated conservatively. No procedure\u2010related mortality or significant morbidity occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Unsedated <jats:styled-content style=\"fixed-case\">TNE<\/jats:styled-content> is safe and feasible for screening synchronous or metachronous esophageal neoplasms in high\u2010risk patients, especially those with head and neck cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12053","type":"journal-article","created":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T03:02:57Z","timestamp":1364785377000},"page":"24-31","source":"Crossref","is-referenced-by-count":42,"title":["Use of transnasal endoscopy for screening of esophageal squamous cell carcinoma in high\u2010risk patients: Yield rate, completion rate, and safety"],"prefix":"10.1111","volume":"26","author":[{"given":"Chih\u2010Hsien","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine National Taiwan University Hospital Yunlin Branch  Yunlin Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chia","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering College of Medicine and College of Engineering National Taiwan University  Taipei Taiwan"},{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Chuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenq\u2010Yuh","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Lun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Internal Medicine Min\u2010Sheng Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tseng\u2010Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Taiwan University Hospital  Taipei Taiwan"},{"name":"Department of Otolaryngology National Taiwan University Hospital Yunlin Branch  Yunlin 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