{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:16:41Z","timestamp":1760955401745},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Red spots on the small bowel mucosa are observed in patients with angioectasia and enteritis. The present study investigated the effectiveness of capsule endoscopy (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>)\u2013flexible spectral imaging color enhancement (<jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content>) as a method for differential diagnosis of the two conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The subjects were 30 patients who underwent <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> and double\u2010balloon endoscopy at <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>okkyo <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital between <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2007 and <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2013. Of these 30 patients, those diagnosed with angioectasia were assigned to <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200913) and those diagnosed with enteritis were assigned to <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200917).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content> at setting 3 and comparing the color intensity of the red spots on a four\u2010step scale (0\u20133), no statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.712) difference was found between the twogroups (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>: 2.69\u2009\u00b1\u20090.48, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>: 2.76\u2009\u00b1\u20090.56). Subjects were considered to show a positive blue sign when areas of blue were observed against the yellow\u2010green background and surrounding the red spots. A comparison of the ratio of positive blue sign for both groups (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>: 15.4%\u2009\u00b1\u200937.6%, <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>roup <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>: 94.1%\u2009\u00b1\u200924.2%) showed a statistically significant increase in the ratio in Group <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of the present study suggest that blue sign may be effective in the differential diagnosis of angioectasia and enteritis in patients with red spots.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12124","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T12:12:58Z","timestamp":1370261578000},"page":"228-231","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of video capsule endoscopy with flexible spectral imaging color enhancement at setting 3 for differential diagnosis of red spots in the small bowel"],"prefix":"10.1111","volume":"26","author":[{"given":"Mitsunori","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Hiraishi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000190403"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-0892-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-1066-z"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082010000200002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2143-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-35686-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01670.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6431.1663"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.007"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70087-1"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.08.005"},{"key":"e_1_2_6_14_1","first-page":"1335","article-title":"[Vascular lesions of the small intestine]","volume":"66","author":"Yano T","year":"2008","journal-title":"Nihon Rinsho"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2010.00988.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.10.016"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2011.584899"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-12-83"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2012.08.004"},{"key":"e_1_2_6_20_1","first-page":"1474","article-title":"Usefulness of flexible spectral imaging color enhancement (FICE) for the detection of angiodysplasia in the preview of capsule endoscopy","volume":"59","author":"Nakamura M","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-2980.2012.00641.x"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12124","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:31:02Z","timestamp":1696318262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.12124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/den.12124"],"URL":"https:\/\/doi.org\/10.1111\/den.12124","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,3]]}}}