{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:00:47Z","timestamp":1765040447538},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T00:00:00Z","timestamp":1373932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Diagnosis of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>rohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) with isolated involvement of the small bowel remains a major challenge. Diagnostic procedures allowing direct insight into the midgut have become available with the introduction of double\u2010balloon enteroscopy (<jats:styled-content style=\"fixed-case\">DBE<\/jats:styled-content>) and video\u2010capsule endoscopy (<jats:styled-content style=\"fixed-case\">VCE<\/jats:styled-content>). The aim of the present study was to evaluate the role of <jats:styled-content style=\"fixed-case\">DBE<\/jats:styled-content> in the diagnosis of isolated <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> of the small bowel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen patients (seven males) with suspected <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> of the small bowel after exclusion of abnormal changes in the upper gastrointestinal tract and colon by esophagogastroduodenoscopy and colonoscopy including histology underwent <jats:styled-content style=\"fixed-case\">DBE<\/jats:styled-content> and high\u2010resolution transabdominal ultrasound.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In seven of 16 (44%) patients, abnormal macroscopic findings were detected by <jats:styled-content style=\"fixed-case\">DBE<\/jats:styled-content> (e.g. ileitis terminalis, inflammatory stenosis, aphthous lesions or jejunal ulcers). In one of thecases, histology confirmed pathognomonic findings consistent with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>. However, the diagnosis of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> was confirmed in 11\/16 (69%) patients taking into account the clinical presentation and course of the disease as well as the endoscopic and imaging results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In cases of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> with clinical expression limited to the small bowel, <jats:styled-content style=\"fixed-case\">DBE<\/jats:styled-content> is a helpful tool. Nevertheless, in these patients, the combination of clinical findings and additional imaging modalities is required for confirmation of the diagnosis. A suggestive medical history, high\u2010resolution ultrasound, <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> and colonoscopy lead the algorithm before the assessment with <jats:styled-content style=\"fixed-case\">DBE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12142","type":"journal-article","created":{"date-parts":[[2013,7,16]],"date-time":"2013-07-16T09:36:54Z","timestamp":1373967414000},"page":"236-242","source":"Crossref","is-referenced-by-count":26,"title":["Double\u2010balloon enteroscopy in the diagnosis of suspected isolated <scp>C<\/scp>rohn's disease of the small bowel"],"prefix":"10.1111","volume":"26","author":[{"given":"Christian","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University of Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"M\u00f6nkem\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University of Magdeburg  Magdeburg Germany"},{"name":"Division of Gastroenterology University of Alabama  Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxi","family":"Salheiser","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University of Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bellutti","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Otto\u2010von\u2010Guericke University of Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Sch\u00fctte","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University of Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Malfertheiner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Diseases Otto\u2010von\u2010Guericke University of Magdeburg  Magdeburg 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