{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:10:09Z","timestamp":1790511009658,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T00:00:00Z","timestamp":1383868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    The usefulness of flexible spectral imaging color enhancement (\n                    <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content>\n                    ) has been reported for evaluating the esophagus, stomach, and small and large intestine. Higher contrast is shown between cancer and the surrounding mucosa in the esophagus and stomach and may facilitate the detection of gastric cancers missed by white light imaging alone. The surface patterns of gastric mucosa are clearly visualized in non\u2010malignant areas but are irregular and blurred in malignant areas, leading to clear demarcation. Capsule endoscopy with\n                    <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content>\n                    detects angiodysplasia and erosions of the small intestine. The surface and vascular pattern with\n                    <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content>\n                    is useful for the differential diagnosis of colorectal polyps. However,\n                    <jats:styled-content style=\"fixed-case\">FICE<\/jats:styled-content>\n                    remains somewhat poor at visualizing mucosal microvasculature on a tumor surface. Narrow\u2010band imaging (\n                    <jats:styled-content style=\"fixed-case\">NBI<\/jats:styled-content>\n                    ) is dark in observing whole gastric mucosa and poor at visualizing mucosal microstructure. Blue laser imaging (\n                    <jats:styled-content style=\"fixed-case\">BLI<\/jats:styled-content>\n                    ) has the potential to resolve these limitations. Narrow\u2010band laserlight combined with white light shows irregular microvessels on both differentiated and undifferentiated gastric cancer similar to those using\n                    <jats:styled-content style=\"fixed-case\">NBI<\/jats:styled-content>\n                    . In addition, irregular surface patterns including minute white zones are clearly seen on the uneven surface of differentiated lesions, resulting in exclusion of undifferentiated lesions. Using both distant and close\u2010up views, a high contrast between green intestinal metaplasia and brown gastric cancer may lead to early detection of gastric cancers and determination of a demarcation line.\n                    <jats:styled-content style=\"fixed-case\">BLI<\/jats:styled-content>\n                    produces high\u2010contrast images in esophageal cancer with clear vision of intrapapillary capillary loops and also predicts the histopathological diagnosis and depth of invasion in colorectal neoplasms.\n                  <\/jats:p>","DOI":"10.1111\/den.12205","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T03:08:16Z","timestamp":1383880096000},"page":"105-115","source":"Crossref","is-referenced-by-count":143,"title":["Present and future status of flexible spectral imaging color enhancement and blue laser imaging 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