{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:04:28Z","timestamp":1765667068008},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T00:00:00Z","timestamp":1386633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Antithrombotic drugs may affect the diagnostic performance of immunochemical fecal occult blood test (<jats:styled-content style=\"fixed-case\">iFOBT<\/jats:styled-content>) for colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) screening. The aim of the present study was to assess the effect of antithrombotic drugs on the diagnostic performance of <jats:styled-content style=\"fixed-case\">iFOBT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 1016 patients who underwent colonoscopy for positive <jats:styled-content style=\"fixed-case\">iFOBT<\/jats:styled-content>. Patients were classified as follows: patients who had advanced neoplasms detected and those who did not; patients who had cancers detected and those who did not; patients who had any neoplasms detected and those who did not. We compared the following factors between two paired groups: sex, age, endoscopists' experience, and antithrombotic drug usage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 139 patients were taking antithrombotic drugs (13.7%). Advanced neoplasms, cancers, and any neoplasms were detected in 196 (19.3%), 59 (5.8%), and 490 (48.2%)patients, respectively. There were no higher detection rates in the antithrombotic drug (\u2013) group than in the (+) group (advanced neoplasms: 19.3% <jats:italic>vs<\/jats:italic> 19.4%, <jats:italic>P<\/jats:italic>\u2009=\u20091.000; cancers: 5.8% <jats:italic>vs<\/jats:italic> 5.8%, <jats:italic>P<\/jats:italic>\u2009=\u20091.000; any neoplasms: 48.4% <jats:italic>vs<\/jats:italic> 47.5%, <jats:italic>P<\/jats:italic>\u2009=\u20090.856). Multivariate logistic regression analysis revealed that none of aspirin, warfarin, or other antithrombotic drugs was a significant factor for advanced neoplasms (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.350\u20131.216, <jats:italic>P<\/jats:italic>\u2009=\u20090.179; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.421\u20131.899, <jats:italic>P<\/jats:italic>\u2009=\u20090.772; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.323\u20131.810, <jats:italic>P<\/jats:italic>\u2009=\u20090.764, respectively). As to cancers and any neoplasms, no antithrombotic drug also proved to be a significant factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study demonstrated that the positive predictive value of <jats:styled-content style=\"fixed-case\">iFOBT<\/jats:styled-content> was not affected by ongoing antithrombotic therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12208","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T02:46:42Z","timestamp":1386730002000},"page":"424-429","source":"Crossref","is-referenced-by-count":11,"title":["Antithrombotic drug does not affect the positive predictive value of an immunochemical fecal occult blood test"],"prefix":"10.1111","volume":"26","author":[{"given":"Yosuke","family":"Tsuji","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Gastroenterology NTT Medical Center Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiaki","family":"Gunji","sequence":"additional","affiliation":[{"name":"Center for Preventive Medicine NTT Medical Center Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Technology Assessment National Institute of Public Health  Wako Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NTT Medical Center Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NTT Medical Center Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Ohata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NTT Medical Center Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutake","family":"Yamamichi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo Japan"},{"name":"Department of Endoscopy and Endoscopic Surgery Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Matsuhashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology NTT Medical Center Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Graduate School of Medicine The University of Tokyo  Tokyo 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