{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:16:55Z","timestamp":1775805415416,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T00:00:00Z","timestamp":1388016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>Malakoplakia in the gastrointestinal tract is rare in healthy young people without underlying disease. Sufficient tissue is required for accurate diagnosis. We describe a malakoplakia that developed in a healthy young woman and was treated by endoscopic mucosal resection (<jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>). A 40\u2010year\u2010old woman with a history of taking oral contraceptives until one year earlier was referred to our hospital with anal bleeding and constipation. A colonoscopy carried out at our another hospital 18 months earlier disclosed no abnormal findings. Colonoscopy at presentation revealed a yellowish\u2010white tumor, 5\u2009mm in diameter, in the rectum. The lesion was slightly protruded and had a smooth flat surface, without erosion or ulceration. <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content> was carried out for a definitive diagnosis. Histopathological examination showed that the tumor contained granular histiocytes, positive for <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content> and negative forcytokeratin (<jats:styled-content style=\"fixed-case\">AE1<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">AE3<\/jats:styled-content>). Several histiocytes contained intracytoplasmic round bodies (<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ichaelis\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>utmann bodies), which reacted positively with periodic acid\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chiff and calcium (<jats:styled-content style=\"fixed-case\">V<\/jats:styled-content>on <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ossa) stains. Intracytoplasmic <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> (von <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ansemann bodies) were identified by <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>iemsa staining. Based on these results, the tumor in the rectum was diagnosed as a malakoplakia. Following <jats:styled-content style=\"fixed-case\">EMR<\/jats:styled-content>, the patient did not receive further treatment for malakoplakia because she had no symptoms associated with malakoplakia. She has been well for more than 9 months, with no symptoms of disease. Awareness of colorectal malakoplakia is important in patients taking steroids, including oral contraceptives.<\/jats:p>","DOI":"10.1111\/den.12222","type":"journal-article","created":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T03:02:44Z","timestamp":1388113364000},"page":"749-751","source":"Crossref","is-referenced-by-count":8,"title":["Endoscopic mucosal resection of a rectal malakoplakia in a healthy adult"],"prefix":"10.1111","volume":"26","author":[{"given":"Harunobu","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Surgery Rokuwa Hospital  Inazawa Japan"},{"name":"Department of Surgery Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Pathology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Surgery Rokuwa Hospital  Inazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rokuwa Hospital  Inazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihito","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rokuwa Hospital  Inazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuyuki","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Surgery Rokuwa Hospital  Inazawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Hatta","sequence":"additional","affiliation":[{"name":"Department of Surgery Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Pathology Fujita Health University School of Medicine  Toyoake Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,26]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"208","article-title":"Ueber Einschlusse in Blasentumoren","volume":"47","author":"Michaelis L","year":"1902","journal-title":"Ztschr. 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