{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:12:03Z","timestamp":1790971923753,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2014,4,20]],"date-time":"2014-04-20T00:00:00Z","timestamp":1397952000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Background and Aim<\/jats:title>To verify the current status in J<\/jats:styled-content>apan on endoscopic diagnosis of superficial non\u2010ampullary duodenal epithelial tumors (SNADET<\/jats:styled-content>) by a multicenter case series through a questionnaire survey.<\/jats:p><\/jats:sec>Methods<\/jats:title>Nine endoscopists and a surgeon responded to a questionnaire on endoscopic diagnosis of SNADET<\/jats:styled-content>. The subjects of this survey were histologically confirmed SNADET<\/jats:styled-content> that were endoscopically or surgically resected from 2007 to 2012. This survey collected data of 364 patients with 396 SNADET<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 396 SNADET<\/jats:styled-content>, 121 were histologically diagnosed as low\u2010grade dysplasia (LGD<\/jats:styled-content>), 112 as high\u2010grade dysplasia (HGD<\/jats:styled-content>), and 163 as superficial adenocarcinoma (SAC<\/jats:styled-content>) including 153 mucosal carcinomas and 10 submucosal carcinomas. Total number of SNADET<\/jats:styled-content> increased from 125 in the first half to 271 in the second half of the survey period. Compared to LGD<\/jats:styled-content>, a significantly greater number of HGD<\/jats:styled-content> or SAC<\/jats:styled-content> was found in the tumors having a diameter >5\u2009mm as well as solitary or predominantly red color. Preoperative endoscopic diagnosis indicated significantly higher sensitivity and accuracy and significantly lower specificity for HGD<\/jats:styled-content> or SAC<\/jats:styled-content> of final histology than preoperative biopsy. Ten submucosal carcinomas had 0\u2010I<\/jats:styled-content> or 0\u2010IIa<\/jats:styled-content>+IIc<\/jats:styled-content> macroscopic\u2010type tumors with red color.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This multicenter case series study suggested that the number of resected SNADET<\/jats:styled-content> is dramatically increasing in J<\/jats:styled-content>apan. Tumor diameter >5\u2009mm and red color seemed to be signs for tumors of HGD<\/jats:styled-content> or SAC<\/jats:styled-content>. Preoperative endoscopy may provide a more reliable diagnosis of final histology of HGD<\/jats:styled-content> or SAC<\/jats:styled-content> than preoperative biopsy. Further studies are warranted for establishing endoscopic features of submucosal carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12277","type":"journal-article","created":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T03:12:32Z","timestamp":1398049952000},"page":"23-29","source":"Crossref","is-referenced-by-count":185,"title":["Endoscopic diagnosis of superficial non\u2010ampullary duodenal epithelial tumors in J<\/scp>apan: M<\/scp>ulticenter case series"],"prefix":"10.1111","volume":"26","author":[{"given":"Kenichi","family":"Goda","sequence":"first","affiliation":[{"name":"Department of Endoscopy The Jikei University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorimasa","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cancer Institute Ariake Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Takimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Takeda General Hospital Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Kakushima","sequence":"additional","affiliation":[{"name":"Division of Endoscopy Shizuoka Cancer Center Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kobe University Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Doyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ishikawa Prefectural Central Hospital Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Gotoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Tokyo Medical University Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Maehata","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noritsugu","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Surgery Kyorin University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2008.10.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480006600110"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-003-0042-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20404"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991215)86:12<2693::AID-CNCR14>3.0.CO;2-U"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/25.4.722"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(96)00244-4"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91228-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200004000-00017"},{"key":"e_1_2_7_11_1","first-page":"95","volume-title":"World Health Organization Classification of Tumours of the Digestive System","author":"Shepherd NA","year":"2010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02159-X"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.422"},{"key":"e_1_2_7_14_1","first-page":"285","article-title":"Endoscopic features of nonampullary duodenal tumors with narrow\u2010band imaging","volume":"57","author":"Yoshimura N","year":"2010","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90807-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(00)70359-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200110000-00004"},{"key":"e_1_2_7_18_1","first-page":"243","article-title":"The epidemiology of cancer of the small bowel","volume":"7","author":"Neugut AI","year":"1998","journal-title":"Cancer Epidemiol. 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