{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T01:16:55Z","timestamp":1782955015126,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Gastric atrophy is one of the important pathological states that cause gastric cancer. As atrophic gastritis is related to the risk of gastric cancer, it is important to diagnose atrophic gastritis. In the present study, we tried to establish endoscopic criteria for atrophic gastritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter study of prospectively collected patients was conducted in 24 participating facilities. Two hundred and seventy\u2010five patients received endoscopic examination and 15 endoscopic features, including diffuse redness, swelling of areae gastrica, and mucosal swelling, were evaluated. Biopsy specimens were taken from five points recommended by the <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>pdated <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ydney <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystem, and evaluated by a single pathologist for atrophy. Sensitivity, specificity, positive predictive value, negative predictive value, area under the receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) of each endoscopic finding to histological atrophy were calculated. Pepsinogen <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> ratios of these patients were measured and compared to the endoscopic features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no single endoscopic feature that is highly specific for histological atrophy. In the corpus, the combination of visibility of vascular pattern and swelling of areae gastrica by indigocarmine chromoendoscopy showed the highest <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> (0.83). In the antrum, the combination of visibility of vascular pattern and mucosal swelling showed the highest <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> (0.70). These endoscopic findings correlated very well to the pepsinogen <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combination of endoscopic findings can improve diagnostic accuracy, and endoscopic diagnosis of atrophy is improved especially with new endoscopic criteria, such as swelling of areae gastrica or mucosal swelling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12286","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T22:05:00Z","timestamp":1396562700000},"page":"709-719","source":"Crossref","is-referenced-by-count":38,"title":["Endoscopic diagnosis of gastric mucosal atrophy: <scp>M<\/scp>ulticenter prospective study"],"prefix":"10.1111","volume":"26","author":[{"given":"Sachiyo","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Ida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Murakami Memorial Hospital Asahi University  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Terao","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Kyoto Min\u2010iren Chuo Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoichi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Clinical Nursing Faculty of Medicine Shimane University  Matsue Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Murakami Memorial Hospital Asahi University  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenobu","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuro","family":"Shimbo","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Informatics International Clinical Research Center Research Institute International Medical Center of Japan  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Research Group for Establishment of Endoscopic Diagnosis of Chronic Gastritis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91877-6"},{"key":"e_1_2_7_3_1","first-page":"775","article-title":"Campylobacter pylori\u2010associated gastritis and immune response in a population at increased risk of gastric carcinoma","volume":"84","author":"Fox JG","year":"1989","journal-title":"Am. 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