{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:05:17Z","timestamp":1758819917292},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,17]],"date-time":"2014-09-17T00:00:00Z","timestamp":1410912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Background and Aim<\/jats:title>The present study aimed to clarify the features and management of non\u2010variceal upper gastrointestinal bleeding (UGIB<\/jats:styled-content>) in J<\/jats:styled-content>apanese patients taking antithrombotic agents.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively investigated the medical records of 560 patients who underwent emergency endoscopy for UGIB<\/jats:styled-content> from 2002 to 2013. The patients were divided into two groups: group A<\/jats:styled-content>, antithrombotic agent use; and group NA<\/jats:styled-content>, no antithrombotic agent use. We compared clinical characteristics, comorbidities, and causes of UGIB<\/jats:styled-content> between the groups. We also investigated management with antithrombotics.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 560 patients with UGIB<\/jats:styled-content>, 27.5% were taking antithrombotics, and this proportion gradually increased during the study period. Mean hemoglobin levels on admission were significantly lower in group A<\/jats:styled-content> (8.0\u2009\u00b1\u20091.7\u2009g\/dL) than in group NA<\/jats:styled-content> (8.9\u2009\u00b1\u20092.9\u2009g\/dL) (P<\/jats:italic>\u2009<\u20090.001). Patients in group A<\/jats:styled-content> developed more gastric ulcers and multiple ulcers than did patients in group NA<\/jats:styled-content>. Incidence of F<\/jats:styled-content>orrest I<\/jats:styled-content>a\u2010type bleeding was lower in group A<\/jats:styled-content> than in group NA<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.001), and the rate of endoscopic hemostasis was significantly higher in group A<\/jats:styled-content> (98.7%) than in group NA<\/jats:styled-content> (94.3%) (P<\/jats:italic>\u2009=\u20090.022). After the release of the 2012 J<\/jats:styled-content>apan G<\/jats:styled-content>astroenterological E<\/jats:styled-content>ndoscopy S<\/jats:styled-content>ociety guidelines, the antithrombotic agent cessation periods were significantly shortened (P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Among patients with UGIB<\/jats:styled-content>, those taking antithrombotics exhibited more severe clinical signs. However spurting hemorrhage was rare. Antithrombotics may be resumed early after endoscopic hemostasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12316","type":"journal-article","created":{"date-parts":[[2014,5,26]],"date-time":"2014-05-26T09:52:53Z","timestamp":1401097973000},"page":"30-36","source":"Crossref","is-referenced-by-count":24,"title":["Characteristics of patients with non\u2010variceal upper gastrointestinal bleeding taking antithrombotic agents"],"prefix":"10.1111","volume":"27","author":[{"given":"Daisuke","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Gastrointestinal Endoscopy Saga Medical School Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastrointestinal Endoscopy Saga Medical School Saga 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