{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:25:31Z","timestamp":1791210331957,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Small, round, yellowish\u2010white nodules (<jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content>) are frequently observed in <jats:styled-content style=\"fixed-case\"><jats:italic>Helicobacter\u2009pylori<\/jats:italic><\/jats:styled-content>\u2010associated gastritis. The aim of the present study was to investigate the clinical significance of these <jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants comprised 211 patients with <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content>\u2010associated gastritis, ranging in age from 23 to 86 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content> were detected in 23% of participants, more frequently in women (33%) than in men (12%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). <jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content> were observed on the antral mucosa in 4.7% of cases, lesser curvature of the corpus mucosa in 20%, greater curvature of the corpus mucosa in 0.9%, and fundic mucosa in 12%. Most <jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content> located on the antral mucosa showed nodular type, and most <jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content> located on the corpus mucosa and fundic mucosa showed flat type. On magnifying endoscopy with narrow\u2010band imaging, <jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content> appeared as round whitish lesions with radial or branching microvessels on the surface and hypovascular globe structures just beneath the surface of the mucosa. Targeted biopsies of <jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content> revealed lymphoid follicles with lymphocyte infiltration or intense inflammatory cell infiltration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The endoscopic finding of <jats:styled-content style=\"fixed-case\">YWN<\/jats:styled-content> could be observed at any site of the gastric mucosa in <jats:styled-content style=\"fixed-case\"><jats:italic>H.\u2009pylori<\/jats:italic><\/jats:styled-content>\u2010associated gastritis, and represented histological lymphoid follicles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12335","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T10:57:48Z","timestamp":1407236268000},"page":"53-60","source":"Crossref","is-referenced-by-count":20,"title":["Endoscopic features of lymphoid follicles in <scp><i>Helicobacter pylori<\/i><\/scp>\u2010associated chronic gastritis"],"prefix":"10.1111","volume":"27","author":[{"given":"Seishu","family":"Hayashi","sequence":"first","affiliation":[{"name":"Division of Hepatology Department of Internal Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"},{"name":"Division of Gastroenterology Department of Internal Medicine Tokyo Metropolitan Health and Medical Treatment Corporation Ookubo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Imamura","sequence":"additional","affiliation":[{"name":"Division of Hepatology Department of Internal Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiminori","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Hepatology Department of Internal Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Saeki","sequence":"additional","affiliation":[{"name":"Division of Hepatology Department of Internal Medicine Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunekazu","family":"Hishima","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01393.x"},{"issue":"1","key":"e_1_2_7_3_1","first-page":"S135","article-title":"Endoscopic diagnosis of gastritis in relation to Helicobacter pylori infection and subjective symptoms","volume":"21","author":"Sakaki N","year":"1995","journal-title":"J. Clin. Gastroenterol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_7_5_1","first-page":"9","article-title":"Endoscopic features of Helicobacter pylori induced gastritis","volume":"5","author":"Khan MQ","year":"1999","journal-title":"Saudi J. Gastroenterol."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-25281"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1605-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1443-1661.2002.00199.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00650.x"},{"key":"e_1_2_7_10_1","first-page":"22","article-title":"Histological spectrum of lymphoid follicles and aggregates in Helicobacter pylori gastritis","volume":"18","author":"Amarapurkar AD","year":"1997","journal-title":"Trop. Gastroenterol."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-7033-2"},{"key":"e_1_2_7_12_1","first-page":"773","article-title":"Chronic gastritis and Helicobacter pylori: A histopathological study of gastric mucosal biopsies","volume":"20","author":"Yakoob MY","year":"2010","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"e_1_2_7_13_1","first-page":"138","article-title":"Frequency of Helicobacter pylori in biopsy proven gastritis and its association with lymphoid follicle formation","volume":"61","author":"Siddiqui ST","year":"2011","journal-title":"J. Pak. Med. Assoc."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.4.325"},{"key":"e_1_2_7_15_1","first-page":"740","article-title":"The significance of lymphoid follicles in the interpretation of gastric biopsy specimens","volume":"118","author":"Genta RM","year":"1994","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018894606541"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(01)80239-X"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1695563"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"e_1_2_7_20_1","first-page":"529","article-title":"Follicular gastritis in adults. Relations with Helicobacter pylori, histological and endoscopic aspects","volume":"17","author":"Zerbib F","year":"1993","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199010000-00005"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199007000-00008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023016000096"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9281-3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(88)96205-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-007-2073-5"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e1acb0"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.11.1226"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90579-8"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2007.00701.x"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12335","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12335","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:59:18Z","timestamp":1696391958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.12335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,3]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/den.12335"],"URL":"https:\/\/doi.org\/10.1111\/den.12335","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,3]]}}}