{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:40:02Z","timestamp":1790563202396,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Duodenal endoscopic submucosal dissection (<jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>) is technically challenging because of anatomical specificities and, to date, has not been validated concerning the high rate of complications such as perforation and delayed bleeding. In the present study, the risk factors for delayed bleeding after duodenal <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content> are presented with the goal of establishing preventive measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 63 patients with non\u2010ampullary superficial duodenal neoplasias treated by <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content> from <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pril 2005 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2014. To analyze the risk factors of delayed bleeding after duodenal <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>, we divided the patients into a delayed bleeding group and a non\u2010bleeding group. To verify the risk factors of delayed bleeding after duodenal <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>, we analyzed various patient\u2010, lesion\u2010, and treatment\u2010related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Delayed bleeding was experienced in 11 patients (17.5%) Univariate analysis of patient\u2010related risk factors of delayed bleeding indicated no significant risk factor. Univariate analysis of lesion\u2010related and treatment\u2010related risk factors indicated only endoscopic closure as a significant risk factor. Multivariate analysis also identified endoscopic closure (not done &gt; done: <jats:italic>P<\/jats:italic>\u2009=\u20090.049) as an independent factor significantly associated with delayed bleeding after duodenal <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>. Hypertension (present &gt; absent: <jats:italic>P<\/jats:italic>\u2009=\u20090.055) showed a non\u2010significant tendency of association by multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This retrospective evaluation found that endoscopic closure was associated with a reduced risk of delayed bleeding after duodenal <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content>. Delayed bleeding after duodenal <jats:styled-content style=\"fixed-case\">ESD<\/jats:styled-content> might be prevented by prophylactic endoscopic closure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12377","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T10:12:05Z","timestamp":1409739125000},"page":"323-330","source":"Crossref","is-referenced-by-count":67,"title":["Delayed bleeding after endoscopic submucosal dissection for non\u2010ampullary superficial duodenal neoplasias might be prevented by prophylactic endoscopic closure: Analysis of risk factors"],"prefix":"10.1111","volume":"27","author":[{"given":"Shu","family":"Hoteya","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Kaise","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Iizuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshifumi","family":"Mitani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Furuhata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kousuke","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Kuribayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"},{"name":"Department of Gastroenterology Shiminnomori Hospital  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Yahagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Toranomon Hospital  Tokyo Japan"},{"name":"Cancer Center Keio University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.11.043"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.3.373"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2168-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12277"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1010470"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200311000-00006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-861287"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1077619"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.04.061"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-1114-y"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2009.00908.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903287551"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2010.01014.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1326178"},{"key":"e_1_2_6_16_1","first-page":"136","article-title":"Endoscopic submucosal dissection for duodenal tumors: A single\u2010center experience","volume":"45","author":"Matsumoto S","year":"2013","journal-title":"Endoscopy"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12273"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05811.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2004.00410.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(04)02033-4"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2012.01376.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys131"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2011.01151.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.07039.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-995530"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12104"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1325799"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1326214"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.10.051"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2012.01363.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12280"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12282"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12377","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12377","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.12377","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12377","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T07:27:15Z","timestamp":1694330835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.12377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,13]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/den.12377"],"URL":"https:\/\/doi.org\/10.1111\/den.12377","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,13]]}}}