{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:18:29Z","timestamp":1773267509715,"version":"3.50.1"},"reference-count":114,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>More than a decade has passed since small\u2010bowel capsule endoscopy (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>) was first reported. Small\u2010bowel <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> is a non\u2010invasive tool that allows visualization of the entire small\u2010intestinal mucosa and facilitates detection of small\u2010intestinal abnormalities. Several studies have shown benefit of small\u2010bowel <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> for certain disorders. Because it is non\u2010invasive, <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> has been applied to other organs including the esophagus, stomach, and colon. The main indications for esophageal <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">ECE<\/jats:styled-content>) are screening for gastroesophageal reflux disease\/<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>arrett's esophagus, and esophageal varices. However, the clinical benefit of <jats:styled-content style=\"fixed-case\">ECE<\/jats:styled-content> is unconfirmed. Magnetically guided <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">MGCE<\/jats:styled-content>) was developed to visualize the gastric mucosa. <jats:styled-content style=\"fixed-case\">MGCE<\/jats:styled-content> is a new concept with room for improvement of capsule navigation and the preparation protocol. Recently, two new small\u2010bowel <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> tools were released. First\u2010generation colon <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content>\u20101) has moderate sensitivity and specificity compared with colonoscopy for colorectal neoplasia surveillance. To obtain higher accuracy, a second\u2010generation <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content>\u20102) was developed with a high sensitivity for detecting clinically relevant polypoid lesions. A possible application of <jats:styled-content style=\"fixed-case\">CCE<\/jats:styled-content> is for inflammatory bowel disease. In the near future, <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> may include diagnostic and therapeutic functions such as magnifying endoscopy systems, targeted biopsy forceps, and drug delivery systems.<\/jats:p>","DOI":"10.1111\/den.12380","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T05:09:14Z","timestamp":1410412154000},"page":"205-215","source":"Crossref","is-referenced-by-count":27,"title":["<i>Current status of capsule endoscopy through a whole digestive tract<\/i>"],"prefix":"10.1111","volume":"27","author":[{"given":"Naoki","family":"Hosoe","sequence":"first","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy School of Medicine Keio University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy School of Medicine Keio University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhiko","family":"Ogata","sequence":"additional","affiliation":[{"name":"Center for Diagnostic and Therapeutic Endoscopy School of Medicine Keio University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013140"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.00274.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.069427"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.06.034"},{"key":"e_1_2_8_6_1","first-page":"21","article-title":"Small bowel tumors in patients undergoing capsule endoscopy: A single center experience","volume":"19","author":"Trifan A","year":"2010","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00603-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12319"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-11-15"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.063685"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300715"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001574-200309000-00008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02206.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000170764.29202.24"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-921034"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-995645"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-944718"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2006.06.035"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01731.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01233.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-921189"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-924975"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.10.022"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22227"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4480"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.66"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1272-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.11.027"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.02.002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.01.064"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.06.053"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.08.053"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.06.016"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2014.20.2.261"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255521"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.09.030"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.2012-0011-RE"},{"key":"e_1_2_8_38_1","article-title":"Magnetically guided capsule versus conventional gastroscopy for upper abdominal complaints: A prospective blinded study","author":"Denzer UW","journal-title":"J. Clin. Gastroenterol."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200608000-00014"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291614"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.07.019"},{"key":"e_1_2_8_42_1","first-page":"141","article-title":"Diagnostic yield of capsule endoscopy in a tertiary hospital in patients with obscure gastrointestinal bleeding","volume":"19","author":"Turenhout ST","year":"2010","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"e_1_2_8_43_1","first-page":"676","article-title":"Timing of capsule endoscopy influences the diagnosis and outcome in obscure\u2010overt gastrointestinal bleeding","volume":"59","author":"Yamada A","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_44_1","first-page":"273","article-title":"Factors predicting the diagnostic yield and intervention in obscure gastrointestinal bleeding investigated using capsule endoscopy","volume":"18","author":"Sidhu R","year":"2009","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e3282fb2a53"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-009-1036-5"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870207"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.06.026"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v5.i11.551"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.05.024"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.35988"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.047"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01058.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.06.008"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2182-9"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3178-3"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.057"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00941.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(03)00453-5"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-944736"},{"key":"e_1_2_8_61_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1155\/2004\/319195","article-title":"Capsule endoscopy: A single\u2010centre experience with the first 226 capsules","volume":"18","author":"Enns R","year":"2004","journal-title":"Can. J. Gastroenterol."},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200409000-00019"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835b7d3a"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2012.704938"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.01.006"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318181b442"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.5754\/hge10736"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.07.035"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.7.763"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243968"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089161209800313"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i47.9043"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.06.035"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.11.055"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)00289-0"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.08.018"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-826041"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200405000-00017"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870315"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870263"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12411"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12161"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.11.022"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-944832"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806347"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256409"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.10.005"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.03.1125"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2010.10.001"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291717"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3206-y"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-944835"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.624"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04458.x"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-10-66"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181dac04b"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1215360"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291611"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i17.2092"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12269"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1310008"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.016"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.07.061"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v5.i11.559"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214790"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-013-1054-3"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1309819"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-012-0965-8"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12005"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12203"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1365413"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2012.6.2.218"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.01.073"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.10.016"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1243994"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12380","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12380","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:31:35Z","timestamp":1694478695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.12380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,20]]},"references-count":114,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/den.12380"],"URL":"https:\/\/doi.org\/10.1111\/den.12380","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,20]]}}}