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Aside from inadequate colon preparation, incomplete examinations (e.g. failure to intubate the cecum), short withdrawal times, and patient\u2010related factors, the primary reason for missing colorectal adenomas and early cancers is poor visualization of the proximal aspect of colonic folds, at anatomical flexures, and in the ileocecal valve area. These anatomical sites tend to be hidden from the standard forward\u2010viewing colonoscope (170\u2010degree angle of view) and can often only be seen through manipulation of the colonoscope by the endoscopist. Thus, there is mounting evidence supporting the need to reduce the adenoma \u2018miss rate\u2019 of standard forward\u2010viewing colonoscopy by improving upon current colonoscope technology and its current visualization\/optics limitations. Recently, there are a number of emerging technologies that may help revolutionize how colonoscopy is carried out and that will significantly reduce adenoma miss rates. These include the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hird <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ye\u00ae <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>etroscope\u00ae and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>hird <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ye\u00ae <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>anoramic<jats:styled-content style=\"fixed-case\"><jats:sup>TM<\/jats:sup><\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>vantis <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ystems, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>unnyvale, <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>); <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>use\u00ae <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ull <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>pectrum <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ndoscopy\u00ae colonoscopy platform (<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>ndo<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hoice <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nc., <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>lpharetta, <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>); 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