{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:32:12Z","timestamp":1773102732873,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T00:00:00Z","timestamp":1438214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Peroral endoscopic myotomy (POEM) is a recently introduced technique for the treatment of achalasia cardia (AC). Data regarding safety and efficacy are still emerging. We report our experience of POEM emphasizing its safety, efficacy and follow\u2010up data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with AC (220; mean age 39\u2009years, range 9\u201374 years) underwent POEM from January 2013 to August 2014 for AC. Retrospective analysis of prospectively collected data was done. POEM was carried out by the standard technique of mucosal incision, submucosal tunneling, and myotomy of the esophageal and gastric muscle bundles followed by closure of the mucosal incision by hemoclips. Eckardt score, high\u2010resolution manometry (HRM) and timed barium esophagogram (TBE) were used to evaluate the results. Post\u2010procedure patients were followed up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Technical success rate of POEM was 96%. At 1\u2009year, clinical success rate was 92%. Mean Eckardt score was 7.2\u2009\u00b1\u20091.55 prior to POEM and 1.18\u2009\u00b1\u20090.74 after POEM (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). There was significant improvement of esophageal emptying on TBE (38.4\u2009\u00b1\u200914.0 % <jats:italic>vs<\/jats:italic> 71.5\u2009\u00b1\u200916.1 % (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). Pre\u2010procedure and post\u2010procedure mean lower esophageal sphincter pressure was 37.5\u2009\u00b1\u200914.5\u2009mmHg and 15.2\u2009\u00b1\u20096.3\u2009mmHg, respectively. (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) Erosive esophagitis was seen in 16% of patients who underwent POEM. There were no major adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Study demonstrates excellent safety profile of POEM with significant relief of symptoms, reduced pressure at HRM and improved emptying at TBE. Further prospective studies are required to compare with other treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12495","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:44:46Z","timestamp":1432737886000},"page":"19-26","source":"Crossref","is-referenced-by-count":82,"title":["Peroral endoscopic myotomy for achalasia cardia: Treatment analysis and follow up of over 200 consecutive patients at a single center"],"prefix":"10.1111","volume":"28","author":[{"given":"Mohan","family":"Ramchandani","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Nageshwar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Darisetty","sequence":"additional","affiliation":[{"name":"Anesthesiology Department Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rama","family":"Kotla","sequence":"additional","affiliation":[{"name":"Anesthesiology Department Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radhika","family":"Chavan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Kalpala","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Galasso","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, \u2018A. Gemelli\u2019 Hospital Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundeep","family":"Lakhtakia","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. V.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology Asian Institute of Gastroenterology  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01639.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0889-8553(21)00676-2","article-title":"Achalasia","volume":"18","author":"Reynolds JC","year":"1989","journal-title":"Gastroenterol. Clin. 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Surg."},{"key":"e_1_2_6_23_1","article-title":"Efficacy of peroral endoscopic myotomy (POEM) in the treatment of achalasia: A systematic review and meta\u2010analysis","author":"Talukdar R","year":"2014","journal-title":"Surg. 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