{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:55Z","timestamp":1787014075879,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,10,26]],"date-time":"2015-10-26T00:00:00Z","timestamp":1445817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Esophageal varices are usually treated with endoscopic injection sclerotherapy (EIS) or endoscopic band ligation (EBL). However, frequent recurrences of varices after those procedures have been problematic. Argon plasma coagulation (APC) after EIS may be effective for preventing varix recurrence and, in recent years, we have routinely carried out APC after EIS. The aim of the present study was to verify the effectiveness of APC for preventing recurrence of varices after EIS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A case\u2013control study was carried out using a historical control cohort in a single center. The varix recurrence rate in 62 patients (34 men and 28 women, median age; 69 years) who underwent APC after EIS for hemorrhagic or risky esophageal varices (APC group) was compared with that of control patients who did not undergo APC after EIS (control group). Age\u2010, sex\u2010, and liver function\u2010matched two control subjects were selected for one case subject (control group). Recurrence of varices was defined as rupture of varices or reappearance of risky varices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 1\u2010year and 2\u2010year recurrence rates of the APC group were 9.7% and 11.3%, respectively. In contrast, the rates of the control group were 29.0% and 34.7%, respectively. Kaplan\u2013Meier curves showed a significantly lower recurrence rate in the APC group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.013, log\u2013rank test). No APC\u2010related severe adverse events were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>APC after EIS was safe and could significantly prevent recurrence of esophageal varices. Therefore, the addition of APC should be routinely carried out after EIS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.12538","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T10:33:14Z","timestamp":1440153194000},"page":"42-49","source":"Crossref","is-referenced-by-count":19,"title":["Argon plasma coagulation is effective for prevention of recurrent esophageal varices after endoscopic injection sclerotherapy: Single\u2010center case\u2013control study"],"prefix":"10.1111","volume":"28","author":[{"given":"Hisanobu","family":"Deguchi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Wakayama Medical University  Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosaku","family":"Moribata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Shingaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Niwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Maekita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikitaka","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ichinose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196412032712301"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00420-8"},{"key":"e_1_2_6_4_1","first-page":"544","article-title":"Prediction of esophageal varices in cirrhosis by per\u2010rectal portal scintigraphy","volume":"37","author":"Shiomi S","year":"1990","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50385"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196302282680905"},{"key":"e_1_2_6_7_1","first-page":"137","article-title":"Over\u2010tube is preferable to free\u2010hand technique to avoid recurrence of varices after endoscopic injection sclerotherapy. Prospective randomized trial","volume":"77","author":"Kitano S","year":"1992","journal-title":"Int. Surg."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800740721"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004649901045"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520802130217"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06265.x"},{"key":"e_1_2_6_12_1","first-page":"42","article-title":"Endoscopic argon plasma coagulation (APC): first clinical experiences in flexible endoscopy","volume":"2","author":"Grund KE","year":"1994","journal-title":"Endosc. Surg."},{"key":"e_1_2_6_13_1","first-page":"71","article-title":"Technology of argon plasma coagulation with particular regard to endoscopic application","volume":"2","author":"Farin G","year":"1994","journal-title":"Endosc. Surg."},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01366968"},{"key":"e_1_2_6_15_1","first-page":"1209","article-title":"Argon plasma coagulation (APC) \u2013 a new and innovative tool for flexible endoscopy","volume":"9","author":"Grund KE","year":"1996","journal-title":"Endosc. Digest."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004159"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004163"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1047634"},{"key":"e_1_2_6_19_1","first-page":"1521","article-title":"Argon plasma coagulation in flexible endoscopy \u2013 the physical principle","volume":"10","author":"Farin G","year":"1998","journal-title":"Endosc. Digest."},{"key":"e_1_2_6_20_1","first-page":"1543","article-title":"Clinical application of argon plasma coagulation in flexible endoscopy","volume":"10","author":"Grund KE","year":"1998","journal-title":"Endosc. Digest."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12804"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70428-8"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(81)73224-3"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80112-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004182"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.1999.01841.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-003-1309-2"},{"key":"e_1_2_6_28_1","first-page":"950","article-title":"Endoscopic variceal ligation versus endoscopic variceal ligation and endoscopic sclerotherapy: a prospective randomized study","volume":"92","author":"Bhargava DK","year":"1997","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001610-200609000-00006"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02128.x"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12538","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12538","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.12538","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T17:16:48Z","timestamp":1694020608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.12538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,26]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/den.12538"],"URL":"https:\/\/doi.org\/10.1111\/den.12538","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,26]]}}}