{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:52:55Z","timestamp":1790837575144,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T00:00:00Z","timestamp":1446422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      We conducted a randomized, double\u2010blinded, placebo\u2010controlled trial to investigate the efficacy of\n                      <jats:italic>Bifidobacterium longum 536<\/jats:italic>\n                      (BB536) supplementation for induction of remission in Japanese patients with active ulcerative colitis (UC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010six patients with mild to moderate UC were enrolled. Three patients had pancolitis, 36 had left\u2010sided colitis, and 17 had proctitis. Patients were randomly treated with 2\u20133\u2009\u00d7\u200910\n                      <jats:sup>11<\/jats:sup>\n                      freeze\u2010dried viable BB536 (28 patients) or placebo (28 patients) for 8\u2009weeks.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 63% of patients receiving BB536 showed clinical remission (UC disease activity index [UCDAI] \u22642) at week 8 compared to 52% of those receiving placebo (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.395). We observed a significant decrease of UCDAI scores (3.8\u2009\u00b1\u20090.4 at baseline to 2.6\u2009\u00b1\u20090.4 at week 8) in the BB536 group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01), whereas there was no significant decrease in the placebo group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.88). There was also a significant decrease in the Rachmilewitz endoscopic index (EI) and the Mayo subscore at week 8 in the BB536 group, whereas there was no significant decrease in the placebo group. A single patient in the BB536 group complained of a mild side\u2010effect, but no other adverse effects were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Supplementation with BB536 was well tolerated and reduced UCDAI scores, EI and Mayo subscores after 8\u2009weeks in Japanese patients with mild to moderately active UC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.12553","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T18:46:45Z","timestamp":1443552405000},"page":"67-74","source":"Crossref","is-referenced-by-count":198,"title":["Efficacy of probiotic treatment with\n                    <i>Bifidobacterium longum 536<\/i>\n                    for induction of remission in active ulcerative colitis: A randomized, double\u2010blinded, placebo\u2010controlled multicenter trial"],"prefix":"10.1111","volume":"28","author":[{"given":"Hiroyuki","family":"Tamaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Takamatsu Red Cross Hospital  Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakase","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Graduate School of Medicine Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Kawanami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kobe City Medical Center Hospital  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinao","family":"Itani","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Nishi Kobe Medical Center  Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Ohana","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Tenri Hospital  Tenri Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Digestive Disease Center Kyoto\u2010Katsura Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Uose","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kansai Electric Power Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hisatsune","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Noe Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahide","family":"Tojo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Otsu Red Cross Hospital  Otsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruyo","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Takamatsu Red Cross Hospital  Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souichi","family":"Arasawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Takamatsu Red Cross Hospital  Takamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Izuta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Takamatsu Red Cross Hospital  Takamatsu 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