{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:56Z","timestamp":1787014076313,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T00:00:00Z","timestamp":1448496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>To demonstrate the effect of endoscopic injection sclerotherapy (EIS) with argon plasma coagulation (APC) as a primary\/secondary prophylaxis for esophageal varies (EV) on portal hemodynamics and long\u2010term outcomes in cirrhosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included 48 cirrhotic patients (64.5\u2009\u00b1\u200911.4\u2009years; 26 bleeders, 22 non\u2010bleeders). Post\u2010treatment outcomes (EIS and APC; median observation period, 12.8\u2009months for recurrence and 21.1\u2009months for prognosis) were evaluated with respect to the findings of hepatic venous catheterization, Doppler ultrasound, and endoscopic ultrasonography (EUS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All patients showed EV eradication after endoscopic treatment, and a decreased frequency of a patent left gastric vein (pre: 83.3%, post: 27.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). However, hepatic venous pressure gradient (HVPG, mmHg) remained unchanged after the treatment, pre: 16.1\u2009\u00b1\u20093.6, post: 15.6\u2009\u00b1\u20093.8 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.269). Cumulative variceal recurrence\/rebleeding rates were 25.5%\/5.6% and 62.4%\/23.1% at 1 and 3\u2009years, respectively. Post\u2010treatment EUS finding, area of submucosal vessels in the cardia \u226512\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      was the only significant factor for variceal recurrence (hazard ratio 9.769, 95% confidence interval 3.046\u201331.337;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cumulative recurrence rate was significantly higher in patients with area of submucosal vessels in the cardia \u226512\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      (58.3% at 1\u2009year and 100% at 3\u2009years) than in those without (11.4% at 1\u2009year and 40.9% at 3\u2009years,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Cumulative overall survival rates were 95.2% and 71.9% at 1 and 3\u2009years, respectively, showing no significant relationship with HVPG.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EIS with APC for EV is unlikely to have a significant influence on portal pressure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/den.12562","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T18:32:16Z","timestamp":1445970736000},"page":"152-161","source":"Crossref","is-referenced-by-count":9,"title":["Eradication of esophageal varices by sclerotherapy combined with argon plasma coagulation: Effect of portal hemodynamics and longitudinal clinical course"],"prefix":"10.1111","volume":"28","author":[{"given":"Takayuki","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Kiyono","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Sekimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Okugawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Yokosuka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nephrology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kawahira","sequence":"additional","affiliation":[{"name":"Center for Frontier Medical Engineering Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Center for Frontier Medical Engineering Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00420-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044456"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21907"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2013.08.004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06265.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840110303"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20236"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.32089"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9096-8"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.31250"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099580"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.6.856"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2009.00929.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.26.11.1226"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/ge.1999.v50.97777"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.1003401"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12804"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150114"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70036-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80586-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050520"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20284"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(97)80112-2"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1443-1661.2003.t01-2-00262.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02956.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-006-1992-x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90453-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-23208"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2008.00415.x"}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12562","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12562","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/den.12562","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T16:17:57Z","timestamp":1694189877000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.12562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,26]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/den.12562"],"URL":"https:\/\/doi.org\/10.1111\/den.12562","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,26]]}}}