{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:19:29Z","timestamp":1784801969125,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Esophageal variceal bleeding is a severe complication of portal hypertension with significant morbidity and mortality. A substantial portion of cirrhotics fail to respond to conventional medical therapy and band ligation, necessitating alternative treatments including self\u2010expanding metal stent (SEMS) placement for acute refractory esophageal variceal bleeding. In the present study, we carried out a systematic review and structured meta\u2010analysis of all eligible studies to evaluate the technical feasibility, safety, clinical efficacy, and survival advantage of SEMS placement for the treatment of of acute esophageal variceal bleeding.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Searches of PubMed, EMBASE, Web of Science, and the Cochrane Library databases were carried out through December 2015. Individual study proportions were transformed into a quantity using the Freeman\u2013Tukey variant of the arcsine square root transformed proportion. Combined weighted proportions, and meta\u2010regression were then determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search yielded 12 studies involving <jats:italic>n<\/jats:italic>\u00a0=\u00a0155 patients included in our meta\u2010analysis. Pooled clinical success rate in achieving hemostasis within 24\u00a0h was 96% (95% CI, 0.90\u20131.00). Technical success for SEMS deployment endoscopically was achieved in 97% of patients (95% CI, 0.91\u20131.00). Total adverse events (including rebleeding after 48\u00a0h, ulceration, and stent migration) were shown in 36% of patients after SEMS placement (95% CI, 0.23\u20130.50). Pooled 30\u2010day and 60\u2010day survival rates were 68% (95% CI, 0.56\u20130.80) and 64% (95% CI, 0.48\u20130.78), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that esophageal SEMS placement is a technically feasible modality and highly efficacious in achieving hemostasis in acute esophageal variceal hemorrhage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12626","type":"journal-article","created":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T14:23:22Z","timestamp":1454595802000},"page":"539-547","source":"Crossref","is-referenced-by-count":56,"title":["Self\u2010expanding metal stents for acute refractory esophageal variceal bleeding: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"28","author":[{"given":"Thomas R","family":"McCarty","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yale University School of Medicine  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basile","family":"Njei","sequence":"additional","affiliation":[{"name":"Section of Digestive Diseases Yale University School of Medicine  New Haven USA"},{"name":"Investigative Medicine Program Yale Center of Clinical Investigation  New Haven USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50385"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198810133191505"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.173"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20339"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07294.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32830280c7"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.06.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01481.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2013.07.023"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22853"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-008-9106-x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1301734"},{"key":"e_1_2_6_15_1","first-page":"S869","article-title":"Early Use of TIPS and Outcomes Patients with Cirrhosis Acute Esophageal Variceal Bleeding: Analysis the U.S. Nationwide Inpatient Sample (NIS) Database, 2000\u20132010. ACG Annual Scientific Meeting 2015","volume":"11","author":"Njei B","journal-title":"Am. J. Gastroenterol."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536031"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.06.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i41.6563"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90867-B"},{"key":"e_1_2_6_20_1","first-page":"103","volume-title":"Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop","author":"Laine L","year":"2011"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-005-7434-9"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-944662"},{"key":"e_1_2_6_23_1","volume-title":"Kendall's Advanced Theory of Statistics","author":"Stuart A","year":"1994"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-008-0009-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.07.028"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335081"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1326227"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.114516"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126525"},{"key":"e_1_2_6_31_1","article-title":"Esophageal balloon tamponade Vs esophageal stent in controlling acute refractory variceal bleeding: A multicenter RCT","author":"Escorsell A","year":"2015","journal-title":"Hepatology"},{"key":"e_1_2_6_32_1","first-page":"S540","article-title":"Self\u2010expanding metal stents: a new hemostasis method for bleeding esophageal varices","volume":"7","author":"Mishin I","year":"2013","journal-title":"Hepatol Int"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350192"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(09)60214-2"},{"key":"e_1_2_6_35_1","unstructured":"BremholmL BendtsenF HansenEF.Self\u2010Expanding Metal Stents for Acute Treatment of Bleeding Oesophageal Varices. Proceedings of Gastro 2009 UEGW\/WCOG London (17th UEGW); 21\u201325 Nov 2009 London UK."}],"container-title":["Digestive Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fden.12626","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/den.12626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T11:20:21Z","timestamp":1696332021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/den.12626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,22]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/den.12626"],"URL":"https:\/\/doi.org\/10.1111\/den.12626","archive":["Portico"],"relation":{},"ISSN":["0915-5635","1443-1661"],"issn-type":[{"value":"0915-5635","type":"print"},{"value":"1443-1661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,22]]}}}