{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T18:24:25Z","timestamp":1747247065829},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Radiofrequency ablation (RFA) and ethanol ablation are accepted methods of tissue destruction for treating cystic tumors. The aim of the present study was to evaluate the feasibility, efficacy, and safety of endoscopic ultrasound (EUS)\u2010guided ablation using normal porcine gallbladders as a substitute model for branch\u2010duct intraductal papillary mucinous neoplasms (BD\u2010IPMN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six adult mini pigs were included in this prospective study. EUS\u2010guided RFA with or without ethanol ablation of the gallbladder was carried out using a prototype 18\u2010gauge endoscopic RFA electrode, and RFA and ethanol ablation were done in a single session. Outcomes were assessed in terms of macroscopic and microscopic evaluations of the treated gallbladders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prototype RFA electrode was used for ablation of the mucosa, aspiration of the internal contents of the gallbladder, and ethanol injection. RFA plus ethanol lavage resulted in a greater mean percentage of denuded gallbladder mucosa (97.5%) than RFA alone (55.8%). Effects of ablation extending to the cystic duct and partially denuded cystic duct mucosae were detected in five of the six pigs. There were no major procedure\u2010related adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EUS\u2010guided ablation of the gallbladder mucosa was feasible and effective in the porcine model. Additional studies will be required to fully assess the risk of procedure\u2010related damage to the main pancreatic duct before using this technique in a clinical setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12628","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T08:46:02Z","timestamp":1455007562000},"page":"599-606","source":"Crossref","is-referenced-by-count":6,"title":["Endoscopic ultrasound\u2010guided ablation of branch\u2010duct intraductal papillary mucinous neoplasms: Feasibility and safety tests using porcine gallbladders"],"prefix":"10.1111","volume":"28","author":[{"given":"Jin\u2010Seok","family":"Park","sequence":"first","affiliation":[{"name":"Digestive Disease Center, Department of Internal Medicine Inha University School of Medicine  Incheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Wan","family":"Seo","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Koo","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung\u2010Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine University of Ulsan College of Medicine, Asan Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000128306.90650.aa"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000124386.54496.15"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-008-2159-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.09.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2006.01.018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/107327480801500407","article-title":"Interdisciplinary management of an intraductal papillary mucinous neoplasm of the pancreas","volume":"15","author":"Nair RM","year":"2008","journal-title":"Cancer Control"},{"key":"e_1_2_8_8_1","first-page":"788","article-title":"Intraductal papillary mucinous neoplasia (IPMN) of the pancreas: its diagnosis, treatment, and prognosis","volume":"108","author":"Grutzmann R","year":"2011","journal-title":"Dtsch. 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