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According to this classification, a type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> tumor, true carcinoma of the cardia, is defined as a cancer within 1\u00a0cm proximal to 2\u00a0cm distal of the EGJ. Histological analysis indicates that the cardiac gland is present with a high degree of frequency between 1\u20132\u00a0cm to the gastric side and 1\u20132\u00a0cm to the esophageal side of the <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content>, which means that this zone can be considered as neither the stomach nor the esophagus but rather as a third zone known as the \u2018<jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> zone\u2019. It has been suggested that there are multiple causes for development of adenocarcinoma in the <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> zone. The <jats:italic><jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> Classification of Malignant Tumours 7th Edition<\/jats:italic> considers <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinoma (<jats:styled-content style=\"fixed-case\">EGJAC<\/jats:styled-content>) occurring in the <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> zone to be a part of esophageal adenocarcinoma (<jats:styled-content style=\"fixed-case\">EAC<\/jats:styled-content>). However, recent studies have indicated that <jats:styled-content style=\"fixed-case\">EGJAC<\/jats:styled-content> behaves differently from <jats:styled-content style=\"fixed-case\">EAC<\/jats:styled-content> and gastric carcinoma. Barrett's esophagus is now considered an important factor in the etiology of <jats:styled-content style=\"fixed-case\">EGJAC<\/jats:styled-content>, but, as yet, no studies have elucidated the differences between cancer arising from short\u2010segment Barrett's esophagus and cancer of the gastric cardia. Thus, there is currently no clinical relevance to subdivision of adenocarcinoma in the <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> zone into above or below the <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> line.<\/jats:p>","DOI":"10.1111\/den.12792","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T10:08:53Z","timestamp":1492682933000},"page":"3-10","source":"Crossref","is-referenced-by-count":28,"title":["Considering the esophagogastric junction as a \u2018zone\u2019"],"prefix":"10.1111","volume":"29","author":[{"given":"Shin","family":"Ichihara","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology Sapporo Kosei General Hospital Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriya","family":"Uedo","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Oncology Osaka Medical Center for Cancer and Cardiovascular Disease Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Gotoda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"605","volume-title":"Histology for Pathologists","author":"El\u2010Zimaity H","year":"2012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31816b444d"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200003000-00009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(87)71676-9"},{"key":"e_1_2_9_7_1","volume-title":"Japanese Classification of Esophageal Cancer","author":"The Japan Esophageal Society","year":"2015"},{"key":"e_1_2_9_8_1","volume-title":"Japanese Classification of Gastric Carcinoma","author":"Japanese Gastric Cancer Association","year":"2010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142826"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182206c0e"},{"key":"e_1_2_9_11_1","first-page":"25","article-title":"Cardia cancer: attempt at a therapeutically relevant classification [Article in German]","volume":"58","author":"Siewert JR","year":"1987","journal-title":"Chirurg"},{"key":"e_1_2_9_12_1","first-page":"173","article-title":"Carcinoma of the cardia: carcinoma of the gastroesophageal junction: classification, pathology and extent of resection","volume":"9","author":"Siewert JR","year":"1996","journal-title":"Dis. 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