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However, in Asian countries, data on the incidence of <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinoma are evidently lacking. In the present review, we focus on the current clinical situation of <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinoma in three Asian countries: Japan, Hong Kong, and Malaysia. The incidence of <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinoma has been reported to be gradually increasing in Malaysia and Japan, whereas it has stabilized in Hong Kong. However, the number of cases in these countries is comparatively low compared with Western countries. A reason for the reported difference in the incidence and time trend of <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinoma among the three countries may be explained by two distinct etiologies: one arising from chronic gastritis similar to distal gastric cancer, and the other related to gastroesophageal reflux disease similar to esophageal adenocarcinoma including Barrett's adenocarcinoma. This review also shows that there are several concerns in clinical practice for <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinoma. In Hong Kong and Malaysia, many <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinomas have been detected at a stage not amenable to endoscopic resection. In Japan, histological curability criteria for endoscopic resection cases have not been established. We suggest that an international collaborative study using the same definition of <jats:styled-content style=\"fixed-case\">EGJ<\/jats:styled-content> adenocarcinoma may be helpful not only for clarifying the characteristics of these cancers but also for improving the clinical outcome of these patients.<\/jats:p>","DOI":"10.1111\/den.12808","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T10:08:53Z","timestamp":1492682933000},"page":"18-25","source":"Crossref","is-referenced-by-count":40,"title":["Different time trend and management of esophagogastric junction adenocarcinoma in three Asian countries"],"prefix":"10.1111","volume":"29","author":[{"given":"Waku","family":"Hatta","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tong","sequence":"additional","affiliation":[{"name":"Division 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