{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:18:03Z","timestamp":1792171083112,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,9]],"date-time":"2017-03-09T00:00:00Z","timestamp":1489017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Endoscopic ultrasound\u2010guided celiac plexus neurolysis (<jats:styled-content style=\"fixed-case\">EUS\u2010CPN<\/jats:styled-content>) is widely used for reducing pain originating from upper abdominal organs. It is mainly indicated to treat pancreatic cancer pain, but also to relieve pain as a result of chronic pancreatitis. Real\u2010time guidance and color Doppler imaging by EUS made the procedure easier and safer, resulting in greater pain relief. Currently, two techniques are used for <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CPN<\/jats:styled-content>. The classic approach, known as the central technique, involves injection of a neurolytic agent at the base of the celiac axis. In the bilateral technique, the neurolytic agent is injected on both sides of the celiac axis. In addition, EUS\u2010guided direct celiac ganglia neurolysis (<jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGN<\/jats:styled-content>) was introduced recently. Pain relief is achieved by <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CPN<\/jats:styled-content> in 70\u201380% of patients with pancreatic cancer and in 50\u201360% of those with chronic pancreatitis. The bilateral technique may be more efficient than the central technique, although the central technique is easier and possibly safer. Moreover, <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CGN<\/jats:styled-content> may provide greater pain relief than conventional <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CPN<\/jats:styled-content>. Procedure\u2010related complications include transient pain exacerbation, transient hypotension, transient diarrhea, and inebriation. Although most complications are not serious, major adverse events such as retroperitoneal bleeding, abscess, and ischemic complications occasionally occur.<\/jats:p>","DOI":"10.1111\/den.12824","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T20:33:46Z","timestamp":1486154026000},"page":"455-462","source":"Crossref","is-referenced-by-count":52,"title":["Endoscopic ultrasound\u2010guided celiac plexus block and neurolysis"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6888-0310","authenticated-orcid":false,"given":"Ichiro","family":"Yasuda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Teikyo University Mizonokuchi Hospital Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,9]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"87","article-title":"Erfahrungen mit Lokalan\u00e4sthesie bei Bauchoperationen","volume":"43","author":"Kappis M","year":"1914","journal-title":"Verh. 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