{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T13:42:18Z","timestamp":1774532538999,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>As society ages, the need for endoscopic retrograde cholangiopancreatography (<jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>) is increasing. This prospective comparative study evaluated the safety and efficacy of midazolam\u2010 versus propofol\u2010based sedations by non\u2010anesthesiologists during therapeutic <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> in patients over 80 years of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 patients over 80 years of age who required therapeutic <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content> were enrolled and randomly received midazolam + fentanyl (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> group) or propofol + fentanyl (<jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> group) sedation. Endoscopic sedation was titrated to a moderate level and carried out by trained registered nurses. Main outcome measurements were sedation safety in terms of cardiopulmonary components and efficacy measured on a 10\u2010point visual analogue scale (<jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding safety, hypoxia occurred in seven (14%) in the <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> group and in eight patients (16%) in the <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> group (<jats:italic>P<\/jats:italic> = 0.779). Increased O<jats:sub>2<\/jats:sub> supply was more frequent in the <jats:styled-content style=\"fixed-case\">PF<\/jats:styled-content> group (32% <jats:italic>vs<\/jats:italic> 42%), albeit not significantly so. There were no differences in the frequency of hypotension, bradycardia or tachycardia between the two groups. Mean <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content> score for overall satisfaction with sedation by patients, endoscopists, and nurses and the scores for pain during the procedures were not different between the two groups. There was no significant difference in the procedure outcomes or rate of <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There were no significant differences of safety and efficacy between midazolam\u2010 and propofol\u2010based sedation in patients over 80 years of age. Increased O<jats:sub>2<\/jats:sub> supply was more frequent in the propofol group, but the prevalence of hypoxia did not differ significantly.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12841","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T11:12:38Z","timestamp":1486638758000},"page":"369-376","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy of midazolam\u2010 versus propofol\u2010based sedations by non\u2010anesthesiologists during therapeutic endoscopic retrograde cholangiopancreatography in patients aged over 80 years"],"prefix":"10.1111","volume":"29","author":[{"given":"Su Jung","family":"Han","sequence":"first","affiliation":[{"name":"Digestive Disease Center Department of Internal Medicine Soonchunhyang University School of Medicine Cheonan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-0761","authenticated-orcid":false,"given":"Tae 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