{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T02:17:37Z","timestamp":1781921857486,"version":"3.54.5"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Chromoendoscopy, narrow\u2010band imaging (NBI<\/jats:styled-content>), and confocal laser endomicroscopy (CLE<\/jats:styled-content>) have been introduced in ulcerative colitis (UC<\/jats:styled-content>)\u2010associated neoplasia surveillance. We aimed to determine the ability of CLE<\/jats:styled-content> to differentiate among UC<\/jats:styled-content>\u2010associated neoplasia (differentiated type or undifferentiated type), sporadic adenoma, and circumscribed regenerative lesions. Of 665 patients with UC<\/jats:styled-content>, we carried out probe\u2010based CLE<\/jats:styled-content> (pCLE<\/jats:styled-content>) on 12 patients with suspected UC<\/jats:styled-content>\u2010associated neoplasia in addition to magnifying chromoendoscopy with crystal violet and NBI<\/jats:styled-content>. We compared pCLE<\/jats:styled-content> findings with pathological diagnoses. pCLE<\/jats:styled-content> could differentiate UC<\/jats:styled-content>\u2010associated differentiated cancer from other pathologies such as solitary adenoma and non\u2010neoplastic circumscribed regenerative lesions on the basis of back\u2010to\u2010back orientation of crypts (P<\/jats:italic> = 0.048), and UC<\/jats:styled-content>\u2010associated undifferentiated cancer from other pathologies on the basis of dark trabecular architecture (P<\/jats:italic> = 0.015). Sensitivity, specificity, and accuracy of combination of back\u2010to\u2010back orientation of crypts and dark trabecular architecture for carcinoma or dysplasia were 100%, 83%, and 92%, respectively. In vivo<\/jats:italic> microscopic observation with pCLE<\/jats:styled-content> was helpful to evaluate the suspected UC<\/jats:styled-content>\u2010associated neoplasia.<\/jats:p>","DOI":"10.1111\/den.12853","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T06:02:41Z","timestamp":1488261761000},"page":"626-633","source":"Crossref","is-referenced-by-count":13,"title":["Usefulness of confocal laser endomicroscopy to diagnose ulcerative colitis\u2010associated neoplasia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-402X","authenticated-orcid":false,"given":"Naoki","family":"Ohmiya","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Horiguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomitsu","family":"Tahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuga","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuo","family":"Nagasaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Fujita Health University School of Medicine Toyoake 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