{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:18:07Z","timestamp":1784715487442,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key Technologies R&D Program","award":["2015BAI13B09"],"award-info":[{"award-number":["2015BAI13B09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestive Endoscopy"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To investigate the efficacy and safety of premedication with simethicone\/Pronase during esophagogastroduodenoscopy (<jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content>) with sedation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six hundred and ten patients were randomly allocated to two groups based on type of premedication given. Premedication used in the control group was 10 mL lidocaine hydrochloride mucilage (<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content>,<jats:italic> N<\/jats:italic> = 314) and premedication used in the intervention group was 80 mL simethicone\/Pronase solution plus 10 mL lidocaine hydrochloride mucilage (<jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content>,<jats:italic> N<\/jats:italic> = 296). <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> was done under sedation. Visibility scores, number of mucosal areas that needed cleansing, water consumption for cleansing, time taken for examination, diminutive lesions, pathological diagnosis, patients\u2019 gag reflex and oxygenation (pulse oximetry) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content> has significantly lower total visibility score than <jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content> (7.978 \u00b1 1.526 <jats:italic>vs<\/jats:italic> 6.348 \u00b1 1.097, <jats:italic>P<\/jats:italic> &lt; 0.01). During the procedure, number of intragastric areas that needed cleansing and amount of water consumed were significantly less in the <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content> than in the <jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content> group (<jats:italic>P<\/jats:italic> &lt; 0.01). In <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content> (<jats:italic>P<\/jats:italic> = 0.01), endoscopy procedure duration was significantly longer. Although there was no significant difference in rate of detection of diminutive lesions between <jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content>, the endoscopist carried out more biopsies in <jats:styled-content style=\"fixed-case\">SP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">LHM<\/jats:styled-content>. This led to a higher rate of diagnosis of atrophic gastritis (<jats:italic>P<\/jats:italic> = 0.014) and intestinal metaplasia (<jats:italic>P<\/jats:italic> = 0.024). There was no significant difference in gag reflex (<jats:italic>P<\/jats:italic> = 0.604) and oxygenation during the endoscopy procedure for either group of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Routine use of premedication with simethicone\/Pronase should be recommended during <jats:styled-content style=\"fixed-case\">EGD<\/jats:styled-content> with sedation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/den.12952","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T10:30:33Z","timestamp":1502965833000},"page":"57-64","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy and safety of using premedication with simethicone\/Pronase during upper gastrointestinal endoscopy examination with sedation: A single center, prospective, single blinded, randomized controlled 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